Recombinant FAP binding proteins and uses thereof

A technology for binding proteins and ankyrins, which can be applied in drug combinations, immunoglobulins, peptide/protein components, etc., and can solve problems such as incomplete understanding of potential effects, complex effects, and incomplete understanding
CN114269366APending Publication Date: 2022-04-01MOLECULAR PARTNERS AG
6 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MOLECULAR PARTNERS AG
Publication Date
2022-04-01

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to recombinant binding proteins comprising a designed ankyrin repeat domain having binding specificity for fibroblast activation protein (FAP). Furthermore, the invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids and such binding proteins, use of nucleic acids or pharmaceutical compositions in methods for localization or delivery of bioactive molecules in FAP-expressing tissues, such as tumor tissues, and for treatment, diagnosis or imaging of diseases, such as cancer, in mammals, including humans.
Need to check novelty before this filing date? Find Prior Art

Description

[0001] Cross references to related patent applications

[0002] This application claims the benefit and priority of European Patent Application EP19178277 filed with the European Patent Office on 04.06.2019. The content of European Patent Application EP19178277 is hereby incorporated by reference in its entirety, including all tables, figures and claims. technical field

[0003] The present invention relates to recombinant binding proteins comprising a designer ankyrin repeat domain with binding specificity for fibroblast activation protein (FAP). Furthermore, the present invention relates to nucleic acids encoding such binding proteins, pharmaceutical compositions comprising such binding proteins or nucleic acids, and the use of such binding proteins, nucleic acids or pharmaceutical compositions for localization or Delivery of biomolecules or bioactive compounds and use in methods of treatment, diagnosis or imaging of diseases, such as cancer, in mammals, including humans. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More