Application of M-type cholinergic receptor agonist and medicine for relieving polydipsia symptom

A receptor agonist, cholinergic technology, applied in the field of medicine, can solve the problems of very few, less attention to diabetes insipidus, and few therapeutic drugs

Pending Publication Date: 2022-04-05
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Generally speaking, there are few studies on the treatment of central diabetes insipidus at present, and there are few treatment drugs available for clinical selection, especially the research on drugs for relieving polydipsia symptoms; moreover, the treatment of mental illness Drug-induced diabetes insipidus has not received much attention

Method used

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  • Application of M-type cholinergic receptor agonist and medicine for relieving polydipsia symptom
  • Application of M-type cholinergic receptor agonist and medicine for relieving polydipsia symptom
  • Application of M-type cholinergic receptor agonist and medicine for relieving polydipsia symptom

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Experimental program
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Embodiment 1

[0065] Animal behavior experiment: Metabolic cage diet, drinking water and activity detection, through animal behavior experiment to detect the peak time of drinking water after single or multiple administrations to find out the intervention time window. According to the experimental grouping, the animals were deprived of water in the metabolic cage for 24 hours in advance to establish a thirsty model. After the water deprivation time was reached, the mice were given intraperitoneal injections of different drugs to be tested, and then immediately placed in the metabolic cage to detect the mice within 1 hour. The amount of drinking water, food intake, and the activity of the mice on the horizontal (x-axis and y-axis) axis and the vertical axis (z-axis), etc., so as to comprehensively analyze the effects of different drugs to be tested, and explore the corresponding mechanism.

[0066] The specific experimental process is as follows:

[0067] 1. Experimental materials:

[0068]...

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Abstract

The invention relates to application of an M-type cholinergic receptor stimulant and a medicine for relieving polydipsia symptoms. The research finds that the M-type cholinergic receptor stimulant can relieve polydipsia symptoms, such as polydipsia symptoms caused by diabetes insipidus and polydipsia symptoms caused by drugs for treating mental diseases. After normative, scientific and rigorous tests and pharmacological experiments, the invention provides the application of the M-type cholinergic receptor stimulant in preparation of medicines for relieving polydipsia symptoms. According to the research, a mental disease treatment medicine and an M-type cholinergic receptor agonist are combined into a new medicine, so that while mental diseases are treated, the symptoms of polydipsia, diabetes insipidus and the like caused by the use of the mental disease treatment medicine can be relieved, the symptoms of polydipsia and diuresis of patients are relieved, and the risk of kidney injury is reduced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of an M-type cholinergic receptor agonist and a medicine for alleviating polydipsia symptoms. Background technique [0002] Diabetes insipidus (DI) is caused by hypothalamic-neurohypophysial lesions that cause arginine vasopressin (AVP), also known as antidiuretic hormone (ADH), to varying degrees, or that the kidneys are sensitive to AVP due to various lesions. A group of clinical syndromes that result in dysfunction of the renal tubules to reabsorb water. The former is central diabetes insipidus (CDI), and the latter is nephrogenic diabetes insipidus (NDI), which is clinically characterized by polyuria, polydipsia, low specific gravity urine or hypoosmolar urine. Among them, central diabetes insipidus (CDI) is mainly a clinical syndrome that occurs after the neurons of the hypothalamus and neurohypophysis are damaged, resulting in decreased secretion of vasopr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/221A61K31/4178A61P13/00A61P25/00
Inventor 鲍进程娟岑华蕊
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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