Application of 4, 4-diisothiocyano stilbene-2, 2-disulfonic acid in preparation of medicine for preventing and/or treating obesity

A technology of isothiocyanate and disulfonic acid, applied in medicine, the field of anion transport inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid

Active Publication Date: 2022-04-08
庹必光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult for most obese patients to adhere to long-term physical activity and sports, so it is still necessary to develop effective drugs for the treatment of obesity

Method used

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  • Application of 4, 4-diisothiocyano stilbene-2, 2-disulfonic acid in preparation of medicine for preventing and/or treating obesity
  • Application of 4, 4-diisothiocyano stilbene-2, 2-disulfonic acid in preparation of medicine for preventing and/or treating obesity
  • Application of 4, 4-diisothiocyano stilbene-2, 2-disulfonic acid in preparation of medicine for preventing and/or treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Effects of prophylactic administration of anion transport inhibitor DIDS on obesity in mice induced by high-fat diet

[0033] Obesity in mice induced by a high-fat diet is a commonly used animal model of obesity in experimental research. In order to study the effect of preventive administration of anion transport inhibitor DIDS on obesity, the present invention selects 5-6 week-old C57BL6 male mice for experiments, and provides high-fat diet to establish an obesity model. Before the occurrence of obesity, the effects of different doses of DIDS on the occurrence of obesity in mice were observed. Two weeks after the high-fat diet was given, the mice were randomly divided into high-fat diet group, control vehicle, and DIDS10mg / kg and 20mg / kg treatment groups. Group). There were 20-22 mice in each group. DIDS was administered intraperitoneally to mice at 10 mg / kg, 20 mg / kg or a control vehicle, once a day, and each group was given a high-fat diet. After 14 weeks of admin...

Embodiment 2

[0038] Effects of Therapeutic Administration of the Anion Transport Inhibitor DIDS on High-Fat Diet-Induced Obesity in Mice

[0039] Obesity in mice induced by a high-fat diet is a commonly used animal model of obesity in experimental research. In order to study the relieving effect of anion transport inhibitor DIDS on obesity, the present invention selects 5-6 week-old C57BL6 male mice for experiments, and gives them a high-fat diet to establish an obesity model. After the occurrence of obesity, observe the relief of obesity in mice given different doses of DIDS. After 16 weeks of high-fat diet administration, mice were randomly divided into high-fat diet group, control vehicle, and DIDS 10mg / kg and 20mg / kg treatment groups after obesity occurred. Each group was given high-fat diet all the time. At the same time, the normal mouse group fed with normal diet was set as normal control (normal group). There were 22-24 mice in each group. DIDS was administered intraperitoneally...

Embodiment 3

[0044] Effects of therapeutic administration of anion transport inhibitor DIDS on abnormal glucose metabolism induced by obesity in mice

[0045] Obesity often causes abnormal glucose metabolism, including increased blood sugar, increased glucose tolerance, and increased insulin resistance. In order to study the relieving effect of anion transport inhibitor DIDS on the abnormal glucose metabolism caused by obesity, the present invention selects 5-6 week-old C57BL6 male mice for experiments, and provides them with a high-fat diet to establish an obesity model. After obesity occurred, observe the effects of different doses of DIDS on blood glucose elevation, glucose tolerance and insulin resistance in mice. After being given a high-fat diet for 16 weeks, the mice were randomly divided into high-fat diet group, control vehicle, and DIDS 10mg / kg and 20mg / kg treatment groups. control. 22-24 mice per group series. DIDS was administered intraperitoneally to mice at 10 mg / kg, 20 mg...

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Abstract

The invention relates to an application of an anion transport inhibitor 4, 4 '-diisothiocyanatostilbene-2, 2'-disulfonic acid in preparation of medicines for preventing and / or treating obesity, and belongs to the technical field of new applications of medicines. The anion transport inhibitor 4, 4 '-diisothiocyano stilbene-2, 2'-disulfonic acid can be applied to preparation of drugs for effectively treating obesity, obesity caused by high-fat diet is effectively relieved, weight is reduced, accumulation of visceral fat, scapular fat and epididymis fat is reduced, and abnormal glucose metabolism caused by obesity is effectively relieved. The application of the anion transport inhibitor 4, 4 '-diisothiocyano stilbene-2, 2'-disulfonic acid in preparation of the medicine for treating obesity is disclosed for the first time, and the anion transport inhibitor 4, 4 '-diisothiocyano stilbene-2, 2'-disulfonic acid has an unexpected effect in the aspect of inhibiting obesity.

Description

technical field [0001] The invention relates to the technical field of new uses of medicines, in particular to anion transport inhibitor 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid , DIDS) in the preparation of medicaments for the prevention and / or treatment of obesity. Background technique [0002] Obesity refers to excessive accumulation and (or) abnormal distribution of fat in the body leading to weight gain. It is a chronic metabolic disease caused by the interaction of multiple factors including genetic and environmental factors. Overweight and obesity, especially abdominal obesity, have a variety of metabolic abnormalities, which are important risk factors for cardiovascular and cerebrovascular diseases, diabetes, certain cancers and some other chronic diseases. [0003] In recent years, with the changes in diet structure and lifestyle, the incidence of obesity in my country has increased significantly. Obesi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/26A61P3/04A61P3/10A61P5/50
CPCY02A50/30
Inventor 庹必光文国容金海朱加兴龙晓英刘雪梅谢睿安家兴
Owner 庹必光
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