High-precision three-spectrum oxyhemoglobin saturation distribution imaging method

Abstract

The invention discloses a high-precision three-spectrum oxyhemoglobin saturation distribution imaging method. The oxyhemoglobin saturation (StO2) can be monitored in vivo in real time, and an anoxic area can be recognized. The method comprises the steps of multi-oxyhemoglobin saturation sample acquisition, three-wavelength image acquisition, image preprocessing, pseudo-color oxyhemoglobin distribution atlas calculation and generation and the like. According to the method, in-vivo in-situ oxyhemoglobin saturation monitoring of in-vivo tissue is achieved in real time, and oxygen deficit spectrum information can be simply, conveniently, rapidly and accurately obtained. According to the method, the limitation that an existing in-vivo blood oxygen imaging technology system is expensive and complex is solved, the high sensitivity of the 660 nm wave band to the blood oxygen saturation degree is brought into full play, calibration of the 405 nm wave band and the 560 nm wave band is combined, and a high-precision and high-resolution real-time hypoxia monitoring map is achieved. Meanwhile, the method can be applied to other endoscopic imaging technologies.

Description

technical field [0001] The invention relates to the technical field of endoscope imaging, in particular to a high-precision three-spectrum blood oxygen saturation distribution imaging method. Background technique [0002] In recent years, as endoscopy has become the main screening method for early cancers, significant progress has been made in improving its imaging technology. Among them, electronic staining imaging technology is more mature, and blood vessels are generally used as specific markers. , because the tumor is an angiogenesis-dependent disease, and its spread will be accompanied by the formation of new blood vessels. This type of method can well distinguish the fine structure of the lesion, but it also has limitations. For example, narrow-band imaging (NBI) and blue laser imaging (BLI) technologies can enhance the capillary network, but the penetration depth is limited; autofluorescence imaging (AFI) technology can improve the detection sensitivity, but the speci...

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Problems solved by technology

[0004] Problems with existing technologies include: (1) Many technologies currently do not have FDA-approved medical devices (2) Existing endoscopic technologies lack the ability to provide physiological parameters (3) Some technologies can perform single-point measurements but cannot provide spatial information (4) There is still a lack of high-precision, high-resolution endoscopic functional imaging methods (5) Technology development lacks standardized performance testing methods, etc.

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