Conch-imitating bioactive scaffold as well as preparation method and application thereof

A bioactive, conch technology, applied in bone implants and other directions, can solve the problems of low cell load rate, limited osteogenic effect, and low function, and achieve the effect of improving biological activity and enhancing cell delivery.

Pending Publication Date: 2022-04-12
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the current 3D printed scaffolds have a certain porous structure, they are mostly composed of solid pillars cross-stacked, it is difficult for cells to migrate to the inside of the scaffold, their biological activity is poor, their structure is simple, their functions are few, and they cannot regulate cell migration behavior. The problem of low cell loading rate makes its internal osteogenesis effect limited, and the lack of osteogenesis environment in some defect parts also makes it difficult to form osteogenesis
At present, the commonly used extrusion 3D printing technology can only build pillar stacking structure brackets, it is difficult to build more complex and fine structures, and its forming accuracy is poor

Method used

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  • Conch-imitating bioactive scaffold as well as preparation method and application thereof
  • Conch-imitating bioactive scaffold as well as preparation method and application thereof
  • Conch-imitating bioactive scaffold as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Use SolidWorks software to design the model of the bionic stent, design a cylindrical imitation conch bioactive stent with a diameter of 13mm and a height of 15mm, the number of through holes in the peripheral wall is 12, the diameter is 1.2mm, and the pitch of the helical nodes is 1.6 , 2.0, 2.4mm three kinds. The designed bionic bracket model data is output as an STL format file, and it is imported into the processing software of the DLP type light-curing 3D printer (purchased from Beijing Shiwei Technology Co., Ltd., the model is AUTOCERA-M) to set parameters and slices. Export it as a 3D printing file format TDP that can be recognized by the printer, and then import the TDP file into a DLP-type stereolithography 3D printer.

[0059] β-TCP powder (purchased from Kunshan Huaqiao Technology New Material Co., Ltd.) 40g, and 17.5g photosensitive resin (epoxy acrylic resin, purchased from Jinhua Marriott Parts Co., Ltd.), 10g 1,6-hexanediol diacrylic acid (HDDA , purchas...

Embodiment 2

[0063] Use SolidWorks software to design the model of the bionic stent, design the cylindrical imitation conch bioactive stent with a diameter of 13 mm and a height of 15 and 30 mm, the pitch of the helical section is 2.4 mm, and the diameter of the through hole on the peripheral wall is 1.2 mm. The number of holes is 8, 12, and 16; when the number of through holes on the peripheral wall is 12, the diameters are 1.0, 1.2, and 1.5mm. One of the through holes in the peripheral wall of the above-mentioned scaffold is replaced by a hole with a diameter of 1.5 mm to communicate with the helical cavity in the middle of the scaffold as a cell addition hole of the scaffold. The designed bionic bracket model data is output as an STL format file, and it is imported into the processing software that comes with the DLP type light-curing 3D printer to set parameters and slices, and exported to the 3D printing file format TDP that the printer can recognize, and then the TDP file Imported in...

Embodiment 3

[0068] Use the SolidWorks software to design the model of the bionic stent, design a cylindrical imitation conch bioactive stent with a diameter of 13mm, a height of 5mm, a diameter of 13mm, and a height of 15mm and a traditional cross-pillar stent, and the number of through holes in the peripheral wall is 12 , with a diameter of 1.2mm, and the pitches of the helical segments are 1.6, 2.0, and 2.4mm respectively. One of the through holes in the peripheral wall of the above-mentioned scaffold is replaced by a hole with a diameter of 1.5 mm to communicate with the helical cavity in the middle of the scaffold as a cell addition hole of the scaffold. The designed bionic bracket model data is output as an STL format file, and it is imported into the processing software that comes with the DLP type light-curing 3D printer to set parameters and slices, and exported to the 3D printing file format TDP that the printer can recognize, and then the TDP file Imported into DLP type light cu...

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Abstract

The invention relates to a conch-imitating bioactive scaffold as well as a preparation method and application thereof. The conch-imitating bioactive stent has the characteristic of a spiral structure; the whole support comprises a middle supporting column, a peripheral wall with a through hole structure, a spiral section and a spiral cavity, wherein the spiral section and the spiral cavity are integrally formed between the middle supporting column and the peripheral wall.

Description

technical field [0001] The invention relates to a conch imitation bioactive scaffold and a preparation method and application thereof, belonging to the field of biological materials. Background technique [0002] Bones are one of the vital organs in the human body, playing a key role in protection, support and body movement. However, due to bone tumors, osteoarthritis (OA) and other lesions, a large number of osteoporosis cases caused by the increasingly serious aging society, and fractures caused by accidents, there is currently a huge clinical demand for bone defect repair. However, due to the limited self-repair ability of bone tissue, the repair of large bone defects is still a difficult problem in clinical treatment. Currently, the main methods for repairing large bone defects include autologous bone graft, allogeneic bone graft and artificial bone graft materials. Autologous bone transplantation is the clinical gold standard, but its application is limited due to its...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/28
Inventor 吴成铁冯博士张猛
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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