Composition of tinidazole suppository as well as preparation method and application of composition

A technology of tinidazole suppository and composition, which is applied in the field of medicine, can solve the problems of slow onset of action and inconvenient treatment, and achieve the effects of stable properties, large specific surface area, and stable melting time limit

Inactive Publication Date: 2022-04-12
JIANGSU YUANHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few medicines for the treatment of mycotic vaginitis on the market, mainly ...

Method used

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  • Composition of tinidazole suppository as well as preparation method and application of composition
  • Composition of tinidazole suppository as well as preparation method and application of composition
  • Composition of tinidazole suppository as well as preparation method and application of composition

Examples

Experimental program
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Effect test

Embodiment 1

[0030] A composition of tinidazole suppositories, each tinidazole suppository contains the following components and parts by weight, 10nm nano tinidazole 0.4g, 36 type mixed fatty acid glycerides 1g, clindamycin hydrochloride 0.05g, Fluconazole 0.1g, surface functionalized nano-zinc oxide 0.05g, 20nm nano-chitosan 0.1g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.1g, boric acid 0.1g, micro Crystalline cellulose starch sodium glycolate 0.05g.

[0031] Nano chitosan is the composition of 0.05g nano carboxymethyl chitosan and 0.05g nano pegylated chitosan, the particle diameter of nano carboxymethyl chitosan and nano pegylated chitosan particles are both 20nm.

[0032] The specific surface area of ​​the surface functionalized nano zinc oxide particles is 10m 2 / g, the particle diameter of this particle is 20nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the following steps: dissolving rosin in isopropano...

Embodiment 2

[0038] A composition of tinidazole suppositories, each tinidazole suppository contains the following components and parts by weight, 15nm nano tinidazole 0.6g, 36 type mixed fatty acid glycerides 1.3g, clindamycin hydrochloride 0.08g , fluconazole 0.15g, surface functionalized nano-zinc oxide 0.08g, 25nm nano-chitosan 0.15g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.15g, boric acid 0.15g, Sodium microcrystalline cellulose starch glycolate 0.06g.

[0039] Nano-chitosan is a composition of 0.06g nanometer carboxymethyl chitosan and 0.08g nanometer PEGylated chitosan, and the particle diameters of nanometer carboxymethyl chitosan and nanometer PEGylated chitosan particles are both 25nm.

[0040] The specific surface area of ​​the surface functionalized nano zinc oxide particles is 100m 2 / g, the particle diameter of this particle is 23nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the steps: dissolvin...

Embodiment 3

[0046] A composition of tinidazole suppository, each tinidazole suppository contains the following components and parts by weight, 20nm nano tinidazole 0.8g, 36 type mixed fatty acid glyceride 1.5g, clindamycin hydrochloride 0.1g , fluconazole 0.2g, surface functionalized nano-zinc oxide 0.1g, 30nm nano-chitosan 0.2g, polydimethyldiallylammonium chloride containing octadecyl hydrophobic group 0.2g, boric acid 0.2g, Sodium microcrystalline cellulose starch glycolate 0.07g.

[0047] Nano-chitosan is a composition of 0.08g nanometer carboxymethyl chitosan and 0.12g nanometer pegylated chitosan, and the particle diameters of nanometer carboxymethyl chitosan and nanometer pegylated chitosan particles are both 30nm.

[0048] The specific surface area of ​​the surface functionalized nano zinc oxide particles is 200m 2 / g, the particle diameter of this particle is 25nm, the preparation method of the nano-zinc oxide of surface functionalization comprises the steps: dissolving rosin i...

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Abstract

The invention belongs to the technical field of medicines, and relates to a suppository for vaginal administration, in particular to a tinidazole suppository composition as well as a preparation method and application thereof. Each tinidazole suppository is prepared from the following components in parts by weight: 0.4 to 0.8 g of nano tinidazole, 1 to 1.5 g of mixed fatty glyceride, 0.05 to 0.1 g of clindamycin hydrochloride, 0.1 to 0.2 g of fluconazole, 0.05 to 0.1 g of surface functionalized nano zinc oxide, 0.1 to 0.2 g of nano chitosan, 0.1 to 0.2 g of poly dimethyl diallyl ammonium chloride, 0.1 to 0.2 g of boric acid and 0.05 to 0.07 g of microcrystalline cellulose starch sodium glycolate. The tinidazole suppository prepared by the invention has excellent pharmaceutical performance and stable and reliable product quality.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to a suppository for vaginal administration, in particular to a composition of tinidazole suppository and its preparation method and application. Background technique [0002] Vaginal infection is one of the very common problematic infectious diseases in gynecology. Due to the infectious diseases caused by different types of microorganisms, these infectious diseases can cause chronic pain, infertility, inflammatory pelvic disease, vulvar itching, Burning, stinging, trouble urinating, dyspareunia, and vaginal foul odor. [0003] If a woman gets a vaginal infection during pregnancy, it can lead to serious problems such as miscarriage, premature delivery, and ectopic pregnancy. Therefore, early prevention, diagnosis or treatment is required. [0004] Microorganisms are often found during vaginal infections, which cause mixed vaginal infections. Vulvovaginitis, vulvitis, and vaginitis are...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K33/30A61K47/04A61K47/38A61K47/60A61K47/51A61P31/04A61P31/10A61P13/00A61P31/12A61P33/02A61K31/4164A61K31/4196A61K31/7056A61K31/722
CPCY02A50/30
Inventor 何井亮贾瑞巧吕国强肖凤轩
Owner JIANGSU YUANHENG PHARMA
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