Bionic liver microfluidic cell culture-drug screening chip

Abstract

The invention relates to the technical field of medicine experiments, and provides a bionic liver micro-fluidic cell culture-medicine screening chip which at least comprises a core plate layer, a bottom plate layer and a top plate layer, the core plate layer and the bionic central vein channel penetrate from the top plate layer to the bottom plate layer; the core plate layer comprises a plurality of hepatocyte culture chambers arranged in a circumferential surrounding mode and bionic capillary channels arranged between the adjacent hepatocyte culture chambers, and the bionic central vein channels penetrate through the centers of the hepatocyte culture chambers arranged in the circumferential surrounding mode; the bottom plate layer is located below the core plate layer and comprises a blood vessel channel, and the blood vessel channel is connected with the bionic central vein channel; and the top plate layer is positioned above the core plate layer and is provided with a flow control connection port. According to the scheme provided by the invention, more accurate metabolic data of the liver cells on the medicine can be obtained.

Description

technical field [0001] The present application relates to the technical field of drug experiments, in particular, the present application relates to a bionic liver microfluidic cell culture-drug screening chip. Background technique [0002] At present, one of the key issues in the fields of drug detection and toxicity screening, disease modeling, disease-related pathophysiology research, and intercellular interactions is how to construct biomimetic tissue structures in vitro. Taking drug screening as an example, it is to accurately simulate the subcellular structure and physiological response of cells in vivo, so as to accurately predict the toxic response of drugs in vivo. The development of new drugs usually includes preclinical drug safety evaluation, such as biochemical analysis, cytology experiments and animal toxicity experiments, and finally applied to the human body. However, most of the candidate new drugs are eliminated in phase III drug clinical trials, so a good...

AI Technical Summary

Problems solved by technology

[0003] Although drug metabolism is completed in the liver, and the functional unit of the liver, the hepatic lobule, plays an important role in drug metabolism, but in most current in vitro studies, there is still a lack of information about the toxicity of oral drugs in the study of liver drug reactions. Research microarray corresponding to liver lobule

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