Mass spectrometer interface device for nanoliter electrospray ionization

Abstract

The invention provides a mass spectrometer interface device for nanoliter electrospray ionization. The device comprises a sampling ionization spray needle and a multi-dimensional adjustment displacement platform used for adjusting the spatial position of the sampling ionization spray needle, the multi-dimensional adjustment displacement platform comprises a sample injection mechanism and a three-dimensional fine adjustment mechanism, the ionization spray needle can be placed on a supporting platform of the three-dimensional fine adjustment mechanism, the supporting platform can apply electrodes, and the electrodes are arranged on the supporting platform. A preset distance exists between the electrode and the sampling ionization spray needle, the three-dimensional fine adjustment mechanism is used for adjusting the position relation between the electrospray spray needle and the mass spectrum sample injection port, and the sample injection mechanism can slide between a first position and a second position, so that the needle taking and replacing operation is completed. The ionization spray needle can be conveniently replaced through rapid sliding, and the position of the spray needle can be accurately adjusted. The three-dimensional fine adjustment mechanism can be used for X-axis adjustment, Y-axis adjustment and Z-axis adjustment, and the three-dimensional fine adjustment mechanism can realize the needle tip movement distance with the highest precision smaller than 10 microns.

Description

technical field [0001] The invention relates to the technical field of electrospray ionization, in particular to a mass spectrometer interface device for nanoliter electrospray ionization. Background technique [0002] Organic mass spectrometry is an analytical method widely used in the field of life science research. Electrospray ionization is a commonly used ionization method for organic mass spectrometers. For example, the announcement number is CN 103972019B "Non-contact DC Induction Electrospray Ionization Device and Ionization Method", which can realize non-contact initiation of electrospray and improve the detection flux of nanoliter electrospray analysis; if the announcement number is CN 106384705 B's "A Microarray-Based High-throughput Nano-liter Electrospray Analysis System and Its Application", which uses a micro-funnel array as a carrier for nano-liter samples, has stable signals, long duration, high sensitivity, and expands advantages such as strong type; as th...

AI Technical Summary

Problems solved by technology

In the actual experiment process, only the position application method of the nano-liter electrospray nozzle is given, which is not convenient for repeated replacement of the nano-liter nozzle. Usually, the nano-liter nozzle is removed and replaced with a new nozzle, which requires a long time position Adjustment is not conducive to high-throughput detection, and the experimental efficiency is low. At the same time, the existing technology cannot observe the nanoliter spray needle well. Usually, the distance between the nanoliter spray needle and the mass spectrometer inlet of 0.5-1mm has an ionization effect. Significant differences lead to unsatisfactory experimental results

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