Preparation method of nano-silver absorbable hemostatic clip with antibacterial effect

An antibacterial and hemostatic clip technology, applied in the field of hemostatic clips, can solve problems such as affecting the effective healing of the surgical site, affecting the prognosis and health of patients, and limiting the scope of application, achieving broad-spectrum antibacterial and bactericidal resistance, promoting wound healing, and no The effect of drug resistance

Inactive Publication Date: 2022-04-26
THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Non-degradable metal clips may induce relevant clinical allergic reactions, which is not safe enough; although biodegradable polymer clips can be degraded, their strength is lower than that of metal clips, and the scope of application is greatly limited
With the development and progress of medicine, people pay more and more attention to the safety of medical services, and gastrointestinal surgery can easily cause abdominal cavity pollution, or the incision is polluted before surgery, which affects the effective healing of the surgical site and leads to surgical failure. The effect becomes worse, and even re-operation debridement seriously affects the patient's prognosis and health

Method used

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Examples

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Effect test

preparation example Construction

[0015] The invention provides a kind of preparation method of nano-silver absorbable hemostatic clip with antibacterial effect, it comprises the following steps:

[0016] Firstly, take granular polylactic acid and carboxymethyl chitosan, ball mill them into powders with specified particle size, and then dry them; since the ball milling reagent added during the ball milling process may cause the powder to become slightly wet, the powders must be dried, thereby It is beneficial to mix evenly with the subsequent drier powder. Then, the above two dry powders, nano-silver powder and nano-titanium dioxide powder are uniformly mixed in proportion to obtain a composite powder, thereby ensuring uniform distribution of nano-silver in the hemostatic clip, and further improving the antibacterial effect of nano-silver. In the process of implementation, the ball milled powder should be ground into a particle size of micron, preferably 10-60 microns, so that there is a large particle size di...

Embodiment 1

[0021] Take 100 parts of granular polylactic acid and 5 parts of carboxymethyl chitosan by mass, grind them to about 60 microns respectively with a ball mill and dry them; take 3 parts of titanium dioxide of about 30 nanometers and 5 parts of nano silver, and mix them evenly Use a 3D printer to print out the V-shaped hemostatic clip. The cross-section of the hemostatic clip was measured to be rectangular, about 1.1 mm in length, and about 0.8 mm in width; the tensile strength was 205.7 MPa, and the yield strength was 135.2 MPa; and clinically used, the hemostatic and antibacterial effects were obvious, and the mechanical properties were good.

Embodiment 2

[0023] Take 100 parts of granular polylactic acid and 7 parts of carboxymethyl chitosan by mass, grind them to about 40 microns respectively with a ball mill and dry them; get about 0.5 parts of titanium dioxide of about 30 nanometers and 15 parts of nano silver, and mix them evenly Use a 3D printer to print out the V-shaped hemostatic clip. The cross-section of the hemostatic clip was measured to be rectangular, about 1.1mm in length and about 0.8mm in width; the tensile strength was 221.2MPa, and the yield strength was 132.8MPa; and clinically used, the hemostatic and antibacterial effects were obvious, and the mechanical properties were good.

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Abstract

The invention relates to a hemostatic clip, in particular to a preparation method of a nano-silver absorbable hemostatic clip with an antibacterial effect, which comprises the following steps: respectively ball-milling granular polylactic acid and carboxymethyl chitosan into powder with specified particle size, and then drying; uniformly mixing the two kinds of dried powder, nano silver powder and nano titanium dioxide powder in proportion to obtain composite powder; and printing the composite powder into the hemostatic clip or the hemostatic clip component by adopting a 3D printer. According to the invention, polylactic acid, nano silver, carboxymethyl chitosan and nano titanium dioxide are adopted as raw materials to prepare the hemostatic clip, so that biodegradation can be realized, and the purpose of absorbability can be achieved; nano-silver is used as a raw material of the hemostatic clip, is a natural antibacterial agent, has the characteristics of broad-spectrum antibacterial sterilization and no drug resistance, and can promote wound healing, improve microcirculation of tissues around a wound, effectively activate and promote growth of tissue cells and reduce generation of scars; the antibacterial agent can be gradually released in a human body, and the antibacterial effect is lasting.

Description

technical field [0001] The invention relates to a hemostatic clip, in particular to a preparation method of a nano-silver absorbable hemostatic clip with antibacterial effect. Background technique [0002] The hemostatic clip is a closure device used for marking, hemostasis or closure of tubular tissue structures in laparoscopic abdominal surgery. It is input into the abdominal cavity according to needs, and the closure device will be forced closed and stored in the delivery device, and then the tubular tissue structure will be closed. organize. The commonly used clinical hemostatic clips have a V-shaped structure and are composed of an arc-shaped elastic clip and a straight clip arm connected to both ends of the clip. Generally, it can be divided into non-degradable metal clips and degradable polymer clips. Non-degradable metal clips may induce relevant clinical allergic reactions, which is not safe enough; although biodegradable polymer clips can be degraded, their streng...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L5/08C08K3/22C08K3/08A61B17/122
CPCC08L67/04A61B17/122C08K2003/2241C08K2003/0806C08K2201/011C08L2201/06C08L5/08C08K3/22C08K3/08
Inventor 陈世杰黄力平彭毅曾晋王栋仝昭宸李劲松苗惊雷王卫国
Owner THE THIRD XIANGYA HOSPITAL OF CENT SOUTH UNIV
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