Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome

A flavonoid compound and acute respiratory distress technology, applied in the field of pharmaceutical research and development, can solve the problems of low curative effect and high dosage of anti-inflammatory pulmonary edema, achieve the effects of low dosage, reduce acute lung injury, and reduce lung wet weight

Pending Publication Date: 2022-05-06
CATCH BIO SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Therefore, the object of the present invention is to solve the problem that the drugs in the prior art cannot improve pulmonary edema while anti-inflammation, and there is a problem of high dosage and low curative effect, thereby providing a kind of isoflavone compound used in the preparation of prevention or treatment of acute Drug use in lung injury

Method used

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  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome
  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome
  • Application of flavonoid compound in preparation of medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The preparation of embodiment 1 compound 1-1~1-15

[0043] 10kg of commercially available fresh spinach was crushed, soaked and extracted with 40L ethanol at room temperature for 10 hours, filtered, and the residue was soaked and extracted with 15L ethanol at room temperature for 6 hours, filtered, the two filtrates were combined, and concentrated under reduced pressure to obtain a crude extract. The obtained crude extract was subjected to column chromatography using XAD1600 macroporous resin, and successively eluted with pure water, 40% ethanol aqueous solution, 65% ethanol aqueous solution, and 95% ethanol aqueous solution, each gradient eluted 3BV, collected and eluted 40%, 65% and 95% ethanol eluent were concentrated under reduced pressure to obtain extract Fr40, Fr65 and Fr95 respectively, and extract Fr40 was carried out column chromatography with SephadexLH-20, and the volume percentage was 5%, 15% %, 25%, 35%, 50%, 100% ethanol aqueous solution for gradient elut...

Embodiment 2

[0050] The preparation of embodiment 2 compound 2-1~2-3

[0051] Get 2kg of plant Aquamarina (dry) purchased from Bozhou city site, use 6L methanol room temperature ultrasonic extraction for 1.5 hours, extract twice, filter, combine extracts, concentrate under reduced pressure to obtain extract, extract extract with 4 times the weight of water dispersion Obtain the suspension, the suspension is successively used sherwood oil, dichloromethane, n-butanol extraction (every kind of extraction solvent is 3 times of suspension volume, extracts three times), the n-butanol extract is concentrated under reduced pressure, with Reversed-phase C18 chromatographic column carries out column chromatography and uses volume percentage to be 5%, 20%, 35%, 50%, 65%, 95% aqueous methanol (both containing 0.3% formic acid by volume percentage) to carry out elution, each 3BV was eluted with a gradient, and the eluents were combined and collected according to the TLC detection results, and concentra...

Embodiment 3

[0054] The preparation of embodiment 3 compound 3-1~3-4

[0055] Get 2.5kg of plant Chenopodium microflora (dry) that Bozhou city place purchases, use 7.5L methanol room temperature ultrasonic extraction for 1.5 hours, extract twice, filter, combine extract, concentrate under reduced pressure to obtain extractum, extract extract with 4 times of weight Dispersed with water to obtain a suspension, the suspension was sequentially extracted with petroleum ether and ethyl acetate (each solvent was 3 times the volume of the suspension, extracted three times), the ethyl acetate extract was concentrated under reduced pressure, and extracted with reversed phase C18 The chromatographic column is subjected to column chromatography, which is eluted with 10%, 25%, 40%, 50%, 65%, and 95% aqueous methanol (both containing 0.3% formic acid) by volume percentage, each gradient 3BV was eluted, and the eluents were combined and collected according to the TLC detection results, and concentrated u...

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Abstract

The invention relates to the technical field of medicine research and development, in particular to application of a flavonoid compound in preparation of a medicine for preventing or treating acute lung injury and/or acute respiratory distress syndrome, the flavonoid compound has a structure as shown in a formula I, r1 is selected from H, a hydroxyl group, an alkyl group of C1-C8, a cycloalkyl group of C3-C10, an alkoxy group of C1-C8 and a glycosyl residue of C4-C20; r2 and R3 are independently selected from one of H, a hydroxyl group, an alkyl group of C1-C8, a cycloalkyl group of C3-C10 and an alkoxy group of C1-C8; and R4 is selected from an aryl group of C5-C20 or a substituted aryl group of C5-C20. The flavonoid compound can obviously relieve inflammatory response of mice with acute lung injury, reduce the ratio of wet weight to dry weight of lungs, inhibit lung edema caused by acute lung injury while resisting inflammation, and can be used as a potential medicine for preventing or treating acute lung injury.

Description

technical field [0001] The invention relates to the technical field of medical research and development, in particular to the application of a flavonoid compound in the preparation of drugs for preventing or treating acute lung injury and / or acute respiratory distress syndrome. Background technique [0002] Acute lung injury (ALI) / acute respiratory distress syndrome (ARDS) is a common clinical critical illness with a high mortality rate, which seriously threatens the lives of critically ill patients. According to statistics, more than 10% of ALI patients need to be admitted to intensive care unit for treatment, and the fatality rate is as high as 32%-55%. bronchial asthma or myocardial infarction etc. on a par. The basic pathophysiological change of ALS / ARDS is non-cardiogenic pulmonary edema caused by increased permeability of alveolar epithelial cells and pulmonary capillary endothelium. Due to alveolar edema and alveolar collapse, severe ventilation / blood flow imbalance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61K31/7048A61K31/357A61P9/10A61P11/00A61P31/04A61P31/12A61P31/14A61P31/22A61P7/10A61P7/08A61P29/00
CPCA61K31/7034A61K31/7048A61K31/357A61P9/10A61P11/00A61P31/04A61P31/12A61P31/14A61P31/22A61P7/10A61P7/08A61P29/00
Inventor 温尧林
Owner CATCH BIO SCI & TECH
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