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Sterile filter without exhaust device and use method

An exhaust device and filter technology, applied in membrane filters, chemical instruments and methods, fixed filter element filters, etc. Simple, avoid leakage, reduce the effect of manual operation errors

Pending Publication Date: 2022-05-06
华兰生物疫苗股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The sterilizer has low safety and narrow scope of application, and cannot sterilize toxic materials
The gasket of the exhaust valve is aging or the exhaust valve is opened by human error, which is likely to cause safety hazards

Method used

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  • Sterile filter without exhaust device and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Utilize the sterile filter without exhaust device of the present application to carry out clarification and filtration to 100L of new coronavirus (SARS-CoV-2) harvest liquid. Three clarification filter elements 13 with a length of 50.8 cm and a pore size of 0.8 μm are installed inside the sterile filter 1 .

[0041] Close the liquid inlet valve 9 and the liquid outlet valve 10 to sterilize the storage tank 7 and the collection tank 8 respectively. After the sterilization is completed, all the new coronavirus harvesting liquid is passed into the storage tank 7. And ensure that the pressure P1 of the storage tank 7 is 0.04MPa, and the pressure P2 of the collection tank 8 is maintained at 0.02MPa. The sterile filter 1, the liquid inlet pipe 4 and the liquid outlet pipe 5 are sterilized online. Start the automatic sterilization program for online sterilization, and the sterilization temperature is 121°C. The sterile filter 1 is in a sealed state at the end of the sterili...

Embodiment 2

[0045] The 2000L rabies virus harvest liquid was clarified and filtered by utilizing the sterile filter without exhaust device of the present application. Fifteen clarification filter elements 13 with a length of 50.8 cm and a pore size of 0.8 μm are installed inside the sterile filter 1 . Start the automatic sterilization program for online sterilization, and the sterilization temperature is 121°C. Concrete operation is with embodiment 1. In this implementation, the pressure in the storage tank 7 is P1 is 0.05MPa, and the pressure in the collection tank 8 is P2 is 0.03MPa. The pressure P3 inside the sterile filter 1 is -0.15MPa after the sterilization is completed and the temperature is lowered to room temperature.

Embodiment 3

[0047] The 1000L 3mol / L NaCl solution was sterilized and filtered using the sterile filter without an exhaust device of the present application. Five filter elements 13 with a length of 25.4 cm and a pore size of 0.45±0.2 μm are installed inside the sterile filter 1 , and an automatic sterilization program is started for on-line sterilization at a sterilization temperature of 121° C. Concrete operation is with embodiment 1. In this implementation, the pressure in the storage tank 7 is P1 which is 0.02MPa, and the pressure in the collection tank 8 is P2 which is 0.01MPa. The pressure P3 inside the sterile filter 1 is -0.10MPa after the sterilization is completed and the temperature is lowered to room temperature.

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Abstract

The invention discloses a sterile filter without an exhaust device, the sterile filter is positioned between a storage tank and a collection tank, the sterile filter comprises a sleeve, a base, a drain pipeline, a liquid inlet pipeline and a liquid outlet pipeline, and a filter element is mounted in the sleeve. The sterile filter does not comprise an exhaust device and is good in sealing performance. The method comprises the following steps: after the mounted filter is subjected to online steam sterilization, negative pressure is formed in the filter, feed liquid to be filtered is forced to enter the sterile filter and flows out of the liquid outlet pipeline after being filtered by the filter element, and the filtration of the feed liquid is completed. The operation that negative pressure is formed after sterilization of the sterile filter and pressure differences are formed between the sterile filter and the storage tank and the collection tank located on the two sides is used for replacing the operation that exhaust is conducted through an exhaust device in the using process, the risk that the exhaust operation causes leakage and loss of to-be-filtered feed liquid is avoided, and the risk that the feed liquid and the environment are subjected to cross contamination is avoided; and the filter is particularly suitable for filtering feed liquid with sterile requirements or feed liquid with the properties of high toxicity, high volatility and the like.

Description

technical field [0001] The invention relates to the technical field of production equipment, in particular to a sterile filter without an exhaust device and a use method thereof. Background technique [0002] In-line sterilization is to automatically pass saturated steam into the filter for sterilization. The traditional filter uses exhaust devices such as the exhaust valve of the sleeve to exhaust the air in the filter at the beginning of filtration, but there will be a problem of leakage loss of the material to be filtered. [0003] A kind of sterilizer pipeline system of CN208693831U, comprises pure water inlet, suction pump, pumping interlocking valve, intake valve, air filter, steam generator, sterilization barrel, exhaust valve, drain valve, condenser, Water vapor separator, pump front-end valve, start valve, vacuum pump and waste water discharge pipe, exhaust valve and sterilization barrel are connected. The sterilizer has low safety and narrow scope of application,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D29/54B01D29/90B01D35/14A61L2/07
CPCB01D29/54B01D29/90B01D35/14A61L2/07B01D2201/20
Inventor 原国强安文珏范蓓崔晓峰刘玉恩王乾芬
Owner 华兰生物疫苗股份有限公司
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