Inhibitor for regulating breast cancer proliferation and migration based on SREBP-1/PI3K/AKT signal channel and application thereof
A signaling pathway and inhibitor technology, applied in the field of biomedicine, can solve the problems of high heterogeneity of breast cancer, arduous treatment tasks, and treatment limitations, and achieve high selectivity, inhibition of breast cancer proliferation and migration, and good effects.
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[0023] In the present invention, based on the existing 6-peptide library, the Cell Counting Kit-8 method is used to initially screen whether the short peptide has an inhibitory effect on the proliferation of breast cancer cells, thereby preliminarily determining that the short peptide sequence is Val-Trp-Arg-Arg-His- Phe. The short peptide sequence was submitted to Shanghai Sangong for solid-phase synthesis, and the synthesized short peptide was subjected to the following experiments to confirm that it can regulate the proliferation and migration of breast cancer by inhibiting the SREBP-1 / PI3K / AKT signaling pathway.
[0024] The data in this study were processed and analyzed using SPSS 22.0 statistical software, and the count data were expressed as mean ± standard deviation (%), the comparison between two groups was carried out by / test, the comparison between multiple groups was carried out by one-way analysis of variance, and the pairwise comparison between groups was carrie...
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