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Application of ginkgolic acid in preparation and treatment of drug for treating vascular restenosis diseases

A technology of ginkgolic acid and restenosis, which is applied in the application field of ginkgolic acid in the preparation and treatment of vascular restenosis drugs

Active Publication Date: 2020-10-13
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on its active ingredients and therapeutic efficacy.

Method used

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  • Application of ginkgolic acid in preparation and treatment of drug for treating vascular restenosis diseases
  • Application of ginkgolic acid in preparation and treatment of drug for treating vascular restenosis diseases
  • Application of ginkgolic acid in preparation and treatment of drug for treating vascular restenosis diseases

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Embodiment 1

[0072] Application of ginkgolic acid in the preparation and treatment of drugs for vascular restenosis, the structural formula of ginkgolic acid is Molecular formula C 24 h 38 o 3 , the molecular weight is 374.5612.

[0073] The preparation method of ginkgolic acid is as follows: the outer testa of ginkgo biloba is peeled off, the drying temperature for the first time is 50°C, the drying time is 50min, the moisture is reduced to 20%, the second drying temperature is 65°C, and the drying time is 45min , the moisture content after drying is 6-10%, crushed to fine particles with a particle diameter of 0.1-0.5 mm, 80% EtOH is refluxed and extracted 3 times at 70°C to obtain a crude extract, and then dissolved with 96% EtOH Become a saturated solution, filter with macroporous resin, and elute with 20%, 40%, 80%, and 95% EtOH in sequence; the eluent is evaporated and dried to a moisture content of 1-2% to obtain the final product of ginkgolic acid C17:1.

[0074] Described gink...

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Abstract

The invention discloses an application of ginkgolic acid in preparation and treatment of a drug for treating vascular restenosis diseases, which comprises the following steps: peeling off gingko testa, drying for 50 minutes at the temperature of 50 DEG C for the first time, reducing the moisture to 20%, drying for 45 minutes at the temperature of 65 DEG C for the second time, drying until the moisture content is 6-10%, and crushing into fine particles with the particle diameter of 0.1-0.5 mm; carrying out reflux extraction on 80% EtOH for 3 times at 70 DEG C to obtain a crude extract, dissolving with 96% EtOH to obtain a saturated solution, filtering with macroporous resin, and sequentially eluting with 20% EtOH, 40% EtOH, 80% EtOH and 95% EtOH; and evaporating and drying the eluent untilthe water content is 1-2% to obtain a final product of ginkgolic acid C17: 1.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and in particular relates to the application of ginkgolic acid in the preparation and treatment of vascular restenosis drugs. Background technique [0002] Vascular remodeling is considered to be the pathophysiological basis of cardiovascular diseases such as hypertension, atherosclerosis and restenosis. Vascular smooth muscle cells (VSMCs) are the major cellular component of arteries and a key determinant of vascular disease. VSMCs can retain a phenotypic change from a differentiated phenotype (contractile phenotype) to a dedifferentiated phenotype (synthetic phenotype) in response to various stimuli. In numerous vascular lesions, VSMCs undergo rapid and reversible changes from a quiescent contractile phenotype to a proliferative and secretory phenotype, characterized by increased proliferation, migration, and extracellular matrix (ECM) production. This synthetic VSMC phenotype has been impli...

Claims

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Application Information

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IPC IPC(8): A61K31/192G01N33/573G01N33/68G01N21/84A61P9/10A61P9/12A61P9/00A61K131/00
CPCA61K31/192A61P9/10A61P9/12A61P9/00G01N33/68G01N33/573G01N21/84A61K2236/15A61K2236/333A61K2236/39A61K2236/53A61K2236/51
Inventor 姚文娟梁秀瑛祁妍陈云刘兆国
Owner NANTONG UNIVERSITY
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