Application of substance inhibiting angiopoietin-like protein 8

Abstract

The invention provides application of a substance inhibiting angiopoietin-like protein 8. The application includes application of the substance inhibiting the angiopoietin-like protein 8 in preparation of products for preventing or treating diseases related to hypertension and / or vascular remodeling. The application of the substance inhibiting the angiopoietin-like protein 8 has the advantages that the substance inhibiting the angiopoietin-like protein 8 inhibits endoplasmic reticulum stress pathways of smooth muscle cells and suppresses proliferation and migration of the smooth muscle cells by inhibiting collagen deposition, and further can effectively reduce the blood pressure and the thickness of blood vessel walls, so that hypertension and vascular remodeling are prevented and treatedeffectively; the substance inhibiting the angiopoietin-like protein 8 can effectively improve the therapeutic effect on hypertension and vascular remodeling when being applied to the products for preventing or treating the diseases related to the hypertension and / or vascular remodeling, thereby having a good application prospect.

Description

technical field [0001] This application relates to the field of biomedical technology, in particular to the application of a substance that inhibits angiopoietin-like protein 8. Background technique [0002] Hypertension (hypertension) refers to an increase in systemic arterial blood pressure (systolic and / or diastolic) as the main feature (systolic blood pressure ≥ 140 mm Hg, diastolic blood pressure ≥ 90 mm Hg), which may be accompanied by heart, brain, kidney, etc. Clinical syndrome of functional or organic damage to organs. [0003] The dilation and contraction of blood vessels, the distribution of blood flow in the lumen and the flow speed of blood in the lumen will change at any time with the body's metabolism and needs. Compared with this significant change in hemodynamics, the structure of the blood vessel wall is relatively stable within a certain range; however, with the development of blood vessel growth and aging process, some obvious changes will occur in its s...

AI Technical Summary

Problems solved by technology

[0005] At present, there are a variety of drugs to lower blood pressure clinically, such as angiotensin II inhibitors, angiotensin II receptor antagonists, calcium ion channel inhibitors, diuretics, etc.; however, the control rate of hypertension is still poor, and hypertension And the incidence of vascular remodeling caused by it is increasing year by year

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