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Metabonomics method for preparing animal model for treating primary dysmenorrhea based on modified inexhaustible tablets

A technology of primary dysmenorrhea and animal model, applied in the field of bioinformatics, can solve the problem of less research on the mechanism of action

Pending Publication Date: 2022-05-13
SHANGHAI JIAO TONG UNIV
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Problems solved by technology

At present, there are few studies on the mechanism of action of Jiawei Meiji Tablets in the treatment of primary dysmenorrhea

Method used

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Embodiment Construction

[0026] The invention provides a metabolomics method for preparing an animal model for treating primary dysmenorrhea based on the Jiawei Meiji Tablet.

[0027] The metabolomics method of the present invention for preparing an animal model of primary dysmenorrhea based on Jiawei Meiji Tablets is a method for non-disease treatment purposes, comprising the following steps:

[0028] (1) Rats were injected subcutaneously with estradiol benzoate, intraperitoneally injected with oxytocin to obtain (i.e. reproduced) the primary dysmenorrhea rat model, and administered Jiawei Meijie Tablets by intragastric administration;

[0029] (2) Through GC-TOF / MS, after modeling, Jiawei Meijiu Tablets were used to intervene and treat the primary dysmenorrhea rat model, and the obtained serum was used to collect metabolic map information;

[0030] (3), performing data preprocessing on the metabolic map information in step (2);

[0031] (4) Perform multivariate statistical analysis to screen biomar...

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Abstract

The invention provides a metabonomics method for preparing an animal model for treating primary dysmenorrhea based on modified inexhaustible tablets, the metabonomics method is a non-disease treatment purpose method, estradiol benzoate and oxytocin are combined to copy a primary dysmenorrhea rat model, the modified inexhaustible tablets are used for performing intervention treatment on the primary dysmenorrhea rat model, and the treatment effect is good. Acquiring metabolic map information of the treated rat serum sample based on a gas chromatography-time-of-flight mass spectrometer; data are processed and analyzed, biomarkers with significant difference are screened out, metabolic pathways in which the biomarkers participate are analyzed through a website, and the action mechanism of the modified inexhaustible tablets for treating primary dysmenorrhea is discussed. According to the method, the influence and change rule of external stimulation on endogenous micromolecules of organisms are researched from the overall perspective, a metabonomics method is matched with the overall view of traditional Chinese medicines, and a new research thought and method are provided for research on traditional Chinese medicine syndromes and the overall action mechanism of the traditional Chinese medicines.

Description

technical field [0001] The invention belongs to the technical field of bioinformatics, and in particular relates to a metabolomics method for preparing and treating primary dysmenorrhea animal models based on Jiawei Meiji Tablets. Background technique [0002] Dysmenorrhea refers to the occurrence of spasmodic pain in the lower abdomen before and after menstruation or during menstruation, and general discomfort, which seriously affects daily life. Divided into two kinds of primary and secondary. Primary dysmenorrhea is functional dysmenorrhea, which refers to menstrual pain, often spasmodic, concentrated in the lower abdomen. Other symptoms include headache, fatigue, dizziness, nausea and vomiting, diarrhea, low back pain, which are very common symptoms in young women and seriously affect the normal work and life of women of childbearing age. The clinical treatment of primary dysmenorrhea advocates the implementation of effective treatment measures as soon as possible, and...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/72G01N30/86A61K49/00
CPCG01N30/02G01N30/06G01N30/72G01N30/86A61K49/0008
Inventor 刘忠李莉伟夏宇飞刘玉敏王波
Owner SHANGHAI JIAO TONG UNIV
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