Methionine metabolic pathway inhibitors

Abstract

The invention provides a novel cystathionine gamma synthase (CGS) inhibitor. They are used as selective and non-selective herbicides, agricultural and non-agricultural herbicides, herbicides in comprehensive control of pests, herbicides for horticulture, cleaning of wastelands, cleaning of industrial or building sites, cleaning of railways and railway embankments, insecticides, fungicides, agricultural plant stimulants or antimicrobial agents. Also provided is a method for controlling or cleaning unwanted vegetation from an area comprising applying to the location of the unwanted vegetation, to the unwanted plant, or to its habitat a herbicidally effective amount of a compound of the invention.

Description

technical field [0001] This application relates to the field of methionine metabolic pathway inhibition. In particular, the application relates to novel cystathionine gamma synthase (CGS) inhibitors, methods for their molecular design and identification based on the structural information obtained, and their use in various agricultural and non-agricultural applications. Background technique [0002] Cystathionine γ-synthase (CGS) is the first enzyme of the transsulfurization pathway in bacteria and plants. In bacteria, sulfide originates from the reduction of sulfate and is incorporated into L-cysteine ​​(L-Cys), which is subsequently converted to L-homocysteine ​​(L-Hcys), which is L - Immediate precursor of methionine (L-Met). This is in contrast to the mammalian reverse transsulfuration pathway for the conversion of L-Hcys to L-Cys. [0003] CGS catalyzes a key step in methionine biosynthesis. CGS, encoded by the metB gene in Escherichia coli (E.coli), catalyzes a pyr...

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Problems solved by technology

However, this structure still has relatively low affinity due to the non-optimal arrangement of functional groups interacting with the phosphate and carboxylate recognition sites

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