Hydrogel patch comprising syneresis mode adjusting filling liquid and preparation method thereof

A hydrogel patch and syneresis technology, applied in skin care preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc., can solve problems not specifically raised, achieve good physical properties, and improve transdermal delivery Effect

Pending Publication Date: 2022-05-27
(株)振科丝特
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In Korean Domestic Application No. 2007-0036270, it is disclosed that the content of iota-carrageenan (Iota-Carrageenan) and locust bean gum is adjusted, and the hydrogel is effective for maintaining the water content, but it is not specifically proposed to improve syneresis when it is attached to the skin Phenomenon

Method used

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  • Hydrogel patch comprising syneresis mode adjusting filling liquid and preparation method thereof
  • Hydrogel patch comprising syneresis mode adjusting filling liquid and preparation method thereof
  • Hydrogel patch comprising syneresis mode adjusting filling liquid and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0041] The preparation method of the hydrogel is performed by dividing the raw materials into the A phase, the B phase and the C phase, and then adding the B and C phases to the A phase after stirring, respectively. Stir at 800 rpm for 5 minutes at 85°C in phase A, at 800 rpm at room temperature for 5 minutes in phase B, and at 800 rpm at room temperature for 5 minutes in phase C. Then, after adding phase B to the said A phase, it stirred at 1000-3000 rpm for about 5 minutes at 70-95 degreeC, and after injecting into C phase, it stirred at 1000-3000 rpm at 70-95 degreeC for about 5 minutes. After applying a high-temperature hydrosol with a roll of 0.1 to 5 mm together with the plastic film paper, it is cooled at 1° C. to normal temperature until the hydrogel reaches normal temperature to complete the hydrogel sheet. In order to measure the pH of the completed hydrogel sheet, 4 g of the hydrogel and 60 g of purified water were put into it, fully swollen on a heating stirrer wit...

Embodiment 1

[0059] Hydrogel Preparation Composition A of Example 1. According to the stirring conditions of the separated phases, phase A was stirred at 85°C at 800 rpm for 5 minutes, phase B was stirred at 800 rpm at room temperature for 5 minutes, and phase C was stirred at 800 rpm at room temperature for 5 minutes. , and stirred at 2000 rpm for 5 minutes at 85°C, and after adding phase C, the mixture was stirred at 85°C at 2000 rpm for 5 minutes. After that, it was coated with a thickness of 2.0 mm, cooled at room temperature, and then molded into a circle having a diameter of 75 mm. The fill liquid of Example 1 prepared Composition C. The stirring conditions of the separated phases were as follows: Phase D was stirred at 800 rpm for 5 minutes at 80°C, Phase E was stirred at 800 rpm for 5 minutes at room temperature, and Phase F was stirred at 800 rpm for 5 minutes at room temperature. , and stirred at 500 rpm for 5 minutes at 80°C, and after adding the F phase, the mixture was stirr...

Embodiment 2

[0061] The same procedure as in Example 1 was carried out, except that a 78 mm circular container was filled so that the hydrogel of the composition A was 80 g and the filling liquid of the composition C was 20 g.

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Abstract

The invention provides a hydrogel patch and a preparation method thereof, wherein the hydrogel patch adjusts the syneresis mode of hydrogel, improves the transdermal delivery of active ingredients, is suitable for cosmetics, and has good physical properties such as gel formation, dosage form stability, use feeling and the like. The patch and the method comprise a hydrogel and a D phase, wherein the hydrogel is formed by mixing a phase A formed by a cross-linking agent and purified water, a phase B formed by organic polymers and polyhydric alcohols and a phase C formed by a pH regulator and purified water, and the D phase is formed by mixing a humectant and purified water. And a filling liquid comprising a phase E comprising a tackifier and a polyol and a phase F comprising a pH regulator and purified water, the hydrogel of the composition A being filled with the filling liquid of the composition C, and the hydrogel of the composition B being filled with the filling liquid of the composition D.

Description

technical field [0001] The present invention relates to a hydrogel patch and a method for preparing the same, and more particularly to a cosmetic product, including a filling solution that can adjust the syneresis mode related to the internal osmotic pressure of the hydrogel, and a water that improves the transdermal delivery of active ingredients. Gel patch and preparation method thereof. Background technique [0002] A hydrogel is a substance in which an organic polymer forms a network structure and occupies water in the vacancy of the network structure, and has a water content of 20 to 80% depending on the application. Hydrogel is a soft substance with outstanding biocompatibility, which can be easily formed in a shape suitable for use, and is used in various fields such as medicine, cosmetics, and prosthesis. In particular, in the cosmetic field, a dosage form is used that induces transdermal delivery of an active ingredient by means of syneresis produced in a hydrogel....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/81A61K8/04A61K8/34A61K8/365A61K8/44A61K8/49A61K8/60A61K8/73A61Q19/00
CPCA61K8/345A61K8/042A61K8/44A61K8/365A61K8/73A61K8/737A61K8/731A61K8/8152A61K8/4946A61K8/60A61Q19/00A61K8/0208A61K2800/48
Inventor 李元珍李定杓
Owner (株)振科丝特
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