Chronic pain treatment target and application thereof

A technology for chronic pain and therapeutic targets, applied in the field of biomedicine, can solve unknown problems
CN114540481AActive Publication Date: 2022-05-27SUZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SUZHOU UNIV
Publication Date
2022-05-27

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Abstract

The invention relates to a chronic pain treatment target, and the treatment target is ALKBH5. The ALKBH5 with high specificity and difference expression in a pain model is provided for the first time, it is found that the chronic pain can be remarkably relieved by reducing the expression of the ALKBH5, it is prompted that the ALKBH5 plays a significant role in occurrence and development of the chronic pain, and new possibility is provided for research, prevention and treatment of chronic pain drugs.
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Description

technical field

[0001] The invention relates to the technical field of biomedicine, in particular to a chronic pain treatment target and application thereof. Background technique

[0002] Chronic pain (such as trigeminal neuralgia, sciatica, cancer pain, migraine, etc.) is a chronic disease that seriously endangers the physical and mental health and quality of life of human beings. The characteristics make patients suffer for a long time, and can induce malignant emotions or mental disorders such as anxiety, depression and fear, and even cause individuals to have suicidal tendencies, seriously endangering patients' lives and quality of life.

[0003] At present, the research on chronic pain treatment drugs has been very extensive. For example, Cao Xiaopan treated trigeminal neuralgia with baclofen combined with adenosylcobalamin (the effect of baclofen combined with adenosylcobalamin in the treatment of trigeminal neuralgia [J]. Chinese Modern Doctors) , 2021, 59(6): 42-44,...

Claims

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