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Sodium hyaluronate gel as well as preparation method and application thereof

A technology of sodium hyaluronate and gel, which can be used in pharmaceutical formulations, prostheses, and drug delivery. It can solve the problems of low elastic modulus and high degree of cross-linking, and achieve high elastic modulus, excellent support performance, and three-dimensional effect. Effect

Active Publication Date: 2022-06-14
ZHEJIANG JINGJIA MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention is to overcome the high degree of cross-linking of sodium hyaluronate gel in the prior art, while the defect of low elastic modulus, provides a A kind of sodium hyaluronate gel and its preparation method and application to overcome the above-mentioned defects

Method used

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  • Sodium hyaluronate gel as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045]Take 5g of sodium hyaluronate and add it to 25ml of 1% sodium hydroxide solution containing 0.27ml of BDDE, shake well, fix it on a beat-type sterile homogenizer, set the parameters 10 times / second, beat for 5 minutes, let stand for 60 minutes, and then again Beat for 5 minutes, stand, 50°C water bath, 2 hours. The samples were washed several times with PBS to achieve swelling equilibrium, particle classification, adding lubricant in proportion, mixing evenly, filling and sterilizing. A sodium hyaluronate gel was prepared.

Embodiment 2

[0047] Take 5g of sodium hyaluronate and add it to 27ml of 1% sodium hydroxide solution containing 0.27ml of BDDE, shake it well, fix it on a beat-type sterile homogenizer, set the parameters 10 times / second, beat for 5 minutes, let stand for 25 minutes, and then again Beat for 5 minutes, stand, 49°C water bath, 3 hours. The samples were washed several times with PBS to achieve swelling equilibrium, particle classification, adding lubricant in proportion, mixing evenly, filling and sterilizing. A sodium hyaluronate gel was prepared.

Embodiment 3

[0049] Take 5g of sodium hyaluronate and add it to 27ml of 1% sodium hydroxide solution containing 0.27ml of BDDE, shake it well, fix it on a beat-type sterile homogenizer, set the parameters 8 times / second, beat for 10 minutes, let stand for 20 minutes, and then again Beat for 10 minutes, stand, 40 ℃ water bath, 4 hours. The samples were washed several times with PBS to achieve swelling equilibrium, particle classification, adding lubricant in proportion, mixing evenly, filling and sterilizing. A sodium hyaluronate gel was prepared.

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Abstract

The invention relates to the field of biomedical materials, in particular to sodium hyaluronate gel and a preparation method and application thereof, the crosslinking degree of the sodium hyaluronate gel is smaller than 5%, and the elastic modulus of the sodium hyaluronate gel is larger than 500 Pa. According to the invention, the mass volume ratio of sodium hyaluronate to the solution is adjusted, and the materials are mixed by combining a beating type sterile homogenizer, so that the finally obtained sodium hyaluronate gel can have extremely high elastic modulus on the premise of low crosslinking degree, and meanwhile, the sodium hyaluronate gel has extremely low BDDE residue, so that the sodium hyaluronate gel is suitable for being used in the field of medical instruments. And the requirements can be effectively met on the basis of ensuring the product performance. And under the condition of equal quantity, the deep injection effect is more stereoscopic, the supporting performance is more excellent, and the device can be applied to injection of deep parts.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a sodium hyaluronate gel and a preparation method and application thereof. Background technique [0002] The modified sodium hyaluronate gel for injection is suitable for filling the sunken parts of the face. The main process is that sodium hyaluronate is dissolved in a sodium hydroxide solution containing BDDE for cross-linking reaction. According to the "Reiblue BDDE Carcinogenic Risk Assessment" report, the cross-linking agent BDDE may have a carcinogenic risk. In the product design process, we ensure product performance while reducing the cross-linking agent BDDE as much as possible. In the case of the same content, the index of cross-linking degree can indirectly reflect the ratio of BDDE. Carry out the ratio, the lower the ratio, the less BDDE, and the safer. [0003] The conventional products on the market have a cross-linking degree of about 9%. Although it still c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L5/08C08J3/24C08J3/075A61L27/20A61L27/50A61L27/52
CPCC08J3/24C08J3/075A61L27/20A61L27/52A61L27/50A61L2400/06A61L2430/34C08J2305/08C08L5/08
Inventor 葛雪飞祁思蕊
Owner ZHEJIANG JINGJIA MEDICAL TECH CO LTD