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Composition for inhibiting HPV (human papillomavirus), preparation and application thereof

A composition and preparation technology, applied in the field of HPV-inhibiting compositions, can solve the problems of high cost and complicated preparation process of therapeutic vaccines, and achieve the effect of long action time, high activity utilization rate and obvious therapeutic effect

Pending Publication Date: 2022-06-24
KUNMING YESHUI BIO TECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to issues of effectiveness and safety, therapeutic vaccines need further research and verification. At the same time, the preparation process of therapeutic vaccines is complicated and costly, and it is difficult to be widely used in the population of developing countries

Method used

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  • Composition for inhibiting HPV (human papillomavirus), preparation and application thereof
  • Composition for inhibiting HPV (human papillomavirus), preparation and application thereof
  • Composition for inhibiting HPV (human papillomavirus), preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The liquid product is prepared with the following raw materials in percentage by weight: 0.5% of chlorinated-2-hydroxy-3-(trimethylamino)propyl polyethylene oxide cellulose ether, and purified water as the balance.

[0024] Preparation: ①. Take the above raw materials according to the mass ratio;

[0025] ②. Pre-dissolving chlorinated 2-hydroxy-3-(trimethylamino)propyl polyethylene oxide cellulose ether in purified water to obtain a homogeneous solution;

[0026] ③. Dispense into suitable containers with a filling machine to obtain finished products.

Embodiment 2

[0028] The raw materials of 8 formulas and their mass ratios are listed in the following table 1, and each formula is taken from its raw materials according to the mass ratios.

[0029] The raw material of table 1 formula 1-formula 8 and mass percentage (%) ratio

[0030]

[0031] S1: Chlorinated-2-hydroxy-3-(trimethylamino)propyl polyethylene oxide cellulose ether; S2: Cationic guar gum; S3: N,N,N-trimethyl-2-(2- Methyl-1-oxo-2-propenyloxy)ethylammonium chloride-acrylamide copolymer.

[0032] 1. HPV gene suppression test

[0033] 1. Test materials and instruments

[0034] 1) Experimental group cells: SiHa (HPV16 positive cervical cancer cells)

[0035] Control cells: HaCaT (human immortalized epidermal cells), used as a control to test the cell-killing ability of the preparation.

[0036] 2) Test sample: formula 1-formula 8

[0037] 3) Cell culture medium: DMEM medium containing 10% fetal bovine serum

[0038] 4) PBS phosphate buffered saline, trypsin

[0039] 5) 12-w...

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PUM

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Abstract

The invention discloses a composition for inhibiting HPV (human papillomavirus), a preparation and application thereof, the active ingredient in the composition is a cationic polymer, and the cationic polymer is a quaternized polysaccharide or / and a quaternized acrylamide copolymer. The composition can effectively inhibit HPV virus activity, can continuously act on a diseased region, almost has no stimulation and toxic and side effects on the diseased region, is high in activity utilization rate, obvious in treatment effect, not complex in preparation process and low in material cost, can be used in cooperation with other conventional treatment strategies, and has wide application prospects. The compound can be used for treating HPV infection and preventing cervical or other tissue lesions caused by HPV infection, and a new way is provided for clinically treating HPV infection and preventing HPV infection.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a composition, preparation and application for inhibiting HPV. Background technique [0002] Human papillomavirus (HPV) is a group of small non-enveloped DNA viruses belonging to the family Papillomaviridae, which can infect human skin and mucosal epithelial tissues, induce verrucous hyperplasia and even cause benign and malignant tumors. At present, more than 100 HPV virus subtypes have been isolated and identified. According to the different infection sites, HPV can be divided into two categories: dermatophilic group and mucosalophilic group. According to the difference of benign and malignant lesions induced by infection, the mucophagic group is divided into ①. High-risk HPV that induces malignant hyperplasia of epithelial tissue. High-risk HPV infection is closely related to the occurrence of cervical cancer and precancerous lesions; ②. Proliferative low-risk type, ...

Claims

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Application Information

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IPC IPC(8): A61K31/717A61K31/736A61K31/785A61K47/36A61K47/32A61P31/20A61P15/00
CPCA61K31/717A61K31/736A61K31/785A61K47/36A61K47/32A61P31/20A61P15/00Y02A50/30
Inventor 张磊陆可望魏洁朱玲周磊
Owner KUNMING YESHUI BIO TECH LTD
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