18F-dodecane positron imaging agent and preparation method thereof

A technology of positron imaging agent and dodecane, which is applied to the preparation of halogenated hydrocarbons, organic chemical methods, chemical instruments and methods, etc., can solve the problems of not being widely used, unable to judge gamma photons, and affecting judgment, and achieve Improve the application surface, provide convenience, and improve the effect of applicability

Pending Publication Date: 2022-06-24
南京航空航天大学深圳研究院
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  • Abstract
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  • Claims
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Problems solved by technology

[0006] At present, there are still some deficiencies in the existing labels: (a) indirect labeling, after the labeling, due to the volatility of kerosene during detection, it is impossible to judge whether the gamma photons are produ

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  • 18F-dodecane positron imaging agent and preparation method thereof
  • 18F-dodecane positron imaging agent and preparation method thereof
  • 18F-dodecane positron imaging agent and preparation method thereof

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Embodiment Construction

[0046] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0047] see figure 1 , the invention provides a kind of synthetic method:

[0048] Synthetic Materials:

[0049] (1) Anhydrous acetonitrile: Sigma-Aldrich, USA,

[0050] (2) K222: 4,7,13,16,21,24-hexaoxy-1,10-diazabicyclo[8,8,8]-hexadecane(4,7,13,16,21, 24-hexaoxa-1, 10-diazabicyclo[8,8,8]-hexacosane), Aldrich, USA,

[0051] (3) The structure of customized precursors and standard products is as follows (precursors and standard prod...

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Abstract

The invention discloses an < 18 > F-dodecane positron imaging agent and a preparation method thereof, is based on a positron nuclide chemical labeling method, and belongs to the field of industrial nondestructive testing. The invention discloses an < 18 > F-dodecane positron imaging agent and a preparation method thereof in order to overcome the defects of an existing marking scheme in accuracy and application range, so that the < 18 > F-dodecane positron imaging agent can determine that gamma photons are generated by burning kerosene instead of volatilized kerosene, the marking accuracy is realized, and the reliability is improved; secondly, the application range of the 18F-dodecane positron imaging agent is not only kerosene, but also can be used for detecting gasoline and aerospace kerosene, so that the application range of the 18F-dodecane positron imaging agent is expanded, and the applicability is improved; meanwhile, the finished product is subjected to structure confirmation and quality control experiment in the preparation process, so that the quality and accuracy of the < 18 > F-dodecane positron imaging agent are ensured.

Description

technical field [0001] The invention relates to the technical field of industrial non-destructive testing, in particular to a 18 F-dodecane positron imaging agent and preparation method thereof. Background technique [0002] C.D.Anderson et al. first observed positron tracks in cosmic rays using cloud chambers in 1932; after that, related theoretical and applied research on positrons has been developed by researchers for nearly a century. Many branches of science; gamma photons are tomographic techniques for imaging particles whose source is produced by the annihilation of positrons. Positrons have the same mass as electrons, and the amount of positive charge equal to the negative charge of electrons, making them an antimatter particle. [0003] At present, the conventional artificial preparation method of positron is to use a cyclotron to continuously bombard the target element in a specific compound with a hydrogen anion (H-) source or a deuterium anion (D-) source as th...

Claims

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Application Information

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IPC IPC(8): C07C19/08C07C17/093G01N30/02G01N30/06G01T1/167
CPCC07C19/08C07C17/093G01N30/02G01N30/06G01T1/167C07B2200/05G01N2030/062
Inventor 肖辉周克印雷磊阎雷刘兼唐吴庆春
Owner 南京航空航天大学深圳研究院
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