Radial and tangential flow bottoms for chromatographic column and chromatographic system combined with same
A chromatographic system and chromatographic column technology, which is applied in the field of chromatographic systems, can solve the problems of not being able to realize high linear flow rate and overloaded sample loading at the same time, not being able to wash or elute the upper part of the column head, and not supporting backwashing of the filter plate, etc. , to achieve excellent distribution effect, high column efficiency, and not easy to clog
Pending Publication Date: 2022-06-28
LISUI TECH SUZHOU
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Problems solved by technology
[0006] Structurally speaking, the separation liquid enters from one end of the chromatographic column and flows out from the other end for collection. Elution; 2. It does not support the reverse flushing of the filter plate (sieve plate), which may easily lead to clogging; 3. It cannot achieve high linear flow rate and overload loading at the same time, and the dynamic load is low
Method used
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[0027] The present invention will be described in further detail below in conjunction with the accompanying drawings.
[0028] figure 1 Schematically shows the cross-sectional structure of a chromatographic system for radial, tangential flow bottom of a chromatographic column and its combined use according to an embodiment of the present invention, figure 2 shown figure 1 Top view of the manifold in . like Figure 1-2 As shown, the system mainly includes a sieve plate 1, a fixing ring 2, a confluence plate 3, a flange plate 4, a spray head 7, a liquid inlet pipe 8 and a return pipe 9 and the like. The sieve plate 1 is fixed on one side (set as the upper side) of the sieve plate fixing ring 2, and the other side (set as the lower side) of the sieve plate fixing ring 2 is mounted on the confluence plate 3, wherein the confluence plate 3 The middle part of the sieve plate protrudes upward, and the sieve plate fixing ring 2 is sleeved and installed on the convex part of the c...
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The invention discloses a radial flow bottom and a tangential flow bottom for a chromatographic column and a chromatographic system combined with the radial flow bottom and the tangential flow bottom. The flow bottom comprises a sieve plate, a fixing ring, a confluence plate and a flange plate, the sieve plate is fixed to the upper side of the sieve plate fixing ring, the lower side of the sieve plate fixing ring is installed on the confluence plate, and the flange plate is installed below the confluence plate. Wherein a transverse upper runner is formed between the confluence plate and the sieve plate, a transverse lower runner is formed between the confluence plate and the flange plate, a circle of vertical runner holes are formed in the confluence plate, and all the runner holes are communicated with the upper runner and the lower runner. According to the radial and tangential flow bottoms for the chromatographic column and the chromatographic system combined with the radial and tangential flow bottoms, tangential flow filtration and chromatographic sample loading can be realized at the same time, an efficient fluid uniform distribution effect is realized, the distribution effect is excellent, and cyclic sample loading and an equilibrium liquid cleaning mode are realized, so that high linear flow velocity and overload sample loading are realized, and extremely high dynamic loading capacity is realized; in addition, the sieve plate can be backwashed and is not easy to block.
Description
technical field [0001] The invention relates to the field of chromatographic columns, in particular to a chromatographic system used for radial and tangential flow bottoms of chromatographic columns and their combined use. Background technique [0002] Large-scale chromatographic separation technology is widely used in the separation and purification of biopharmaceuticals and general macromolecular materials, and is the key technology for industrialized high-purity separation. The chromatographic separation step usually requires pretreatment of the material, and the existing column head distributor of the chromatographic column does not have the ability to handle the material with particles or precipitates, so it must be used in conjunction with centrifugation and filtration equipment. Therefore, although the separation efficiency is high, it usually involves many steps and a long process. [0003] In addition, due to the high flow resistance of the chromatographic column, ...
Claims
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Patent Timeline
Login to View More IPC IPC(8): B01D15/22B01D15/42B01D15/14B01D15/18
CPCB01D15/22B01D15/424B01D15/14B01D15/18
Inventor 赵庆利金祖伟周胜黄宇峰金博闻
Owner LISUI TECH SUZHOU