Application of pulsatilla saponin B4 in preparation of external medicine for treating psoriasis
A technology of Pulsatilla saponins and external medicines, which is applied in the field of medicine and can solve the problems of obvious side effects and large doses
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Embodiment 1
[0034] Example 1 The effect of Pulsatilla saponin B4 on the PASI score of psoriatic mice
[0035] The experimental results showed that after applying imiquimod, compared with the blank group, the skin of the model group appeared erythema, scaling and infiltration, resulting in psoriasis-like skin lesions. With the continuous effect of the drug, the skin lesions in the model group became more and more serious from the 2nd day, the scales increased and thickened, and the skin infiltration was obvious. The scientific significance indicates that the psoriasis mouse model was successfully established. Compared with the model group, the skin lesions in the high-dose Pulsatilla saponin group were significantly relieved during the same period, the skin was smoother, with almost no erythema and scales, and the infiltration and thickening were very light; the skin of the halometasone-positive drug group was slightly reddish, with less scales and infiltration. Thickening is mild (see f...
Embodiment 2
[0036] Example 2 The effect of Pulsatilla saponin B4 on the erythema score of psoriatic mice
[0037] The erythema on the back of the mice in the model group and the low-dose group began to appear after the 3rd day of medication, and the erythema score increased day by day until the 7th day of the curative effect observation period. , until the 7th day, the erythema began to subside during the observation period, while the skin of the mice in the high-dose group had almost no erythema. Among them, the erythema scores of the model group and the control group were significantly different from 3 to 7 days (P image 3 ). The experimental results suggest that Pulsatilla saponins can significantly reduce the degree of erythema in mice with psoriasis, and the effect is better than that of glucocorticoids.
Embodiment 3
[0038] Example 3 The effect of Pulsatilla saponin B4 on the scale score of mice with psoriasis
[0039] The scales on the back of the mice in the model group and the low-dose group began to appear after the 4th day of treatment, and the scale scores increased day by day until the 7th day of efficacy observation period, while the back of the mice in the high-dose group only began to appear fine scales after the 7th day of treatment. , the positive drug group did not appear scales for 7 days. Among them, there were statistically significant differences in the scale scores between the model group and the control group on days 4-5 (P Figure 4 ). The experimental results suggest that Pulsatilla saponins can significantly reduce the scale of psoriatic mice, and the effect is comparable to that of glucocorticoids.
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