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Wound dressing for hemostasis and wound healing and preparation method thereof

A technology of wound dressing and test method, which is applied in the direction of dressing, non-adhesive dressing, bandage, etc., and can solve the problems of dosage form, use field and use method that cannot provide multiple methods, etc.

Active Publication Date: 2022-07-08
MEDITIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] And regarding wound dressings using collagen and hyaluronic acid, Korean Laid-Open Patent No. 2013-0009651 discloses a chondrocyte therapeutic agent comprising collagen, hyaluronic acid derivatives, and stem cells derived from mammalian umbilical cords, but It is a method of simply mixing collagen and hyaluronic acid, and there is a problem that it cannot be formulated to achieve its purpose without using a chemical cross-linking substance
In addition, there is also the disadvantage that the dosage form that can be used can only be the dry phase dosage form, so it has the limitation that it cannot provide various methods in terms of the field of use and the method of use.

Method used

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  • Wound dressing for hemostasis and wound healing and preparation method thereof
  • Wound dressing for hemostasis and wound healing and preparation method thereof
  • Wound dressing for hemostasis and wound healing and preparation method thereof

Examples

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preparation example Construction

[0026] The object of the present invention is to provide a preparation method of a wound dressing, the wound dressing comprising the following steps:

[0027] (A) a step of mixing an aqueous solution containing 0.4 to 1 weight percent of hyaluronic acid or a salt thereof, 0.1 to 0.5 weight percent of collagen, and 0.3 to 0.6 weight percent of sodium chloride;

[0028] (B) a step of adjusting the pH of the aqueous solution to 6 to 8;

[0029] (C) the step of freeze-drying the aqueous solution to make it into a pad shape;

[0030] (D) the step of maintaining the freeze-dried sheet unchanged or adjusting the thickness by compression; and

[0031] (D) a step of sterilizing the sheet on which the freeze-drying and thickness adjustment have been completed with ethylene oxide gas (EO gas), gamma rays or electron beams.

[0032] The wound dressing according to the present invention is characterized in that the wound dressing is a pharmaceutical composition or a quasi-drug compositio...

specific Embodiment

[0048] In the following, various embodiments will be presented to assist the understanding of the present invention. These examples are provided only to facilitate understanding of the present invention, and the scope of the present invention is not limited to these examples.

[0049]

Embodiment 1

[0050] Example 1: Preparation of wound dressing according to the mixing ratio of hyaluronic acid (HA), collagen and sodium chloride

[0051] Sodium hyaluronate, Atelo collagen (porcine type I collagen) and sodium chloride were stirred according to the mixing ratio shown in Table 1 to prepare an aqueous solution, and each aqueous solution was 13.5 g ± 2% The proportion of the package is divided into 5 × 5 cm mold. Then, freeze-drying was performed according to the procedure described in Table 4, and the texture of the resulting wound dressing was evaluated.

[0052] 【Table 1】

[0053]

[0054] 【Table 2】

[0055]

[0056]It was found that the wound dressing of method 1 has a texture that is easily damaged by physical stimulation, and the wound dressing of method 8 has a hard texture and is difficult to deform into a desired shape, so it is difficult to realize commercialization. In contrast, the wound dressings of methods 2 to 7 have a soft texture similar to existing...

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Abstract

The invention relates to a wound dressing for hemostasis and wound healing and a preparation method thereof. More specifically, the invention relates to a preparation method of a wound dressing, when the wound dressing is prepared by the preparation method, by adjusting the mixing ratio of hyaluronic acid and collagen and freeze-drying conditions, the wound dressing which not only has an optimal wound healing promoting effect and an adhesion preventing effect, but also has an anti-adhesion effect can be prepared. And the wound dressing also has excellent economical efficiency and commercial property.

Description

technical field [0001] The invention relates to a wound dressing for hemostasis, prevention of adhesion and wound healing and a preparation method thereof. More specifically, the present invention relates to a preparation method of a wound dressing. The preparation method can prepare a wound dressing by adjusting the mixing ratio of hyaluronic acid (HA) and collagen and freeze-drying conditions. Not only has the best wound healing promoting effect and anti-adhesion effect, but also has excellent economical and commercial wound dressing. Background technique [0002] Wound refers to a state in which the continuity of tissue is disrupted by external pressure. The healing process of wounds is generally divided into three steps: inflammation, proliferation and maturation. In order to treat wounds, an ideal dressing should be used to prevent the wound from being exposed to the external environment, thereby preventing infection and inhibiting the inflammatory response. As a biol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/22
CPCA61L2/00A61L15/22A61F13/00A61L15/32A61L15/28A61L15/225A61L15/325A61F13/00987A61L2/0035A61L2/007A61F2013/00463A61F13/01012
Inventor 柳廷熙朴寄焕宣明周赵梨黃哲周金基勋
Owner MEDITIP