Chitosan-based efficient hemostatic with Janus structure as well as preparation method and application of chitosan-based efficient hemostatic

The technology of chitosan and hemostatic agent is applied in the field of chitosan-based high-efficiency composite hemostatic agent and its preparation, and achieves the effects of rapid hemostasis, avoidance of secondary trauma and good biodegradability

Active Publication Date: 2022-07-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the average particle size of esterified microporous starch / calcium carbonate Janus particles is 10 μm, which has the risk of entering human blood circulation through wounds

Method used

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  • Chitosan-based efficient hemostatic with Janus structure as well as preparation method and application of chitosan-based efficient hemostatic
  • Chitosan-based efficient hemostatic with Janus structure as well as preparation method and application of chitosan-based efficient hemostatic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040]A kind of chitosan-based high-efficiency composite hemostatic agent with Janus structure, the formula includes the following raw materials in parts by weight and the raw materials include the following components in parts by weight:

[0041] 5 parts of chitosan, 12 parts of methacrylic anhydride, 1 part of acetic acid, 10 parts of calcium carbonate, 80 parts of calcium chloride, 2 parts of photoinitiator Irgacure2959, 200 parts of carboxylated chitosan, 2 parts of hydrochloric acid, tranexamic acid 5 parts acid, 20 parts sodium hydroxide.

[0042] The recipe includes the following steps:

[0043] a. Dissolve chitosan in a preconfigured 2wt% acetic acid aqueous solution to obtain a 2wt% chitosan solution, add methacrylic anhydride, heat and react at 50°C for 2h, put the mixed solution into a dialysis bag for dialysis purification, Then, it was pre-cooled in a -40°C refrigerator for 12 hours, and lyophilized in a freeze dryer for 24-72 hours to obtain chitosan methacrylat...

Embodiment 2

[0053] A kind of chitosan-based high-efficiency composite hemostatic agent with Janus structure, the formula includes the following raw materials in parts by weight and the raw materials include the following components in parts by weight:

[0054] 8 parts of chitosan, 30 parts of methacrylic anhydride, 4 parts of acetic acid, 26 parts of calcium carbonate, 160 parts of calcium chloride, 3 parts of photoinitiator Irgacure2959, 260 parts of carboxylated chitosan, 4 parts of hydrochloric acid, dihydrogen phosphate 18 parts salt, 55 parts sodium hydroxide.

[0055] The recipe includes the following steps:

[0056] a. Dissolve chitosan in a pre-configured 2wt% acetic acid aqueous solution to obtain a 3wt% chitosan solution, add methacrylic anhydride, heat and react at 30°C for 4h, put the mixed solution into a dialysis bag for dialysis purification, Then put it in a -24°C refrigerator for 24h, and freeze-dry it in a freeze dryer for 24-72h to obtain chitosan methacrylate;

[005...

Embodiment 3

[0064] A kind of chitosan-based high-efficiency composite hemostatic agent with Janus structure, the formula includes the following raw materials in parts by weight and the raw materials include the following components in parts by weight:

[0065] 10 parts of chitosan, 36 parts of methacrylic anhydride, 5 parts of acetic acid, 20 parts of calcium carbonate, 200 parts of calcium chloride, 4 parts of photoinitiator Irgacure2959, 300 parts of carboxylated chitosan, 3 parts of hydrochloric acid, hydrogen sulfate 12 parts, 70 parts sodium hydroxide.

[0066] The recipe includes the following steps:

[0067] a. Dissolve chitosan in a pre-configured 2wt% acetic acid aqueous solution to obtain a 2.5wt% chitosan solution, add methacrylic anhydride, heat and react at 35°C for 3h, put the mixed solution into a dialysis bag for dialysis purification , then pre-cooled in a -40°C refrigerator for 8h, and freeze-dried in a freeze dryer for 24-72h to obtain chitosan methacrylate;

[0068] ...

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Abstract

The invention discloses a chitosan-based high-efficiency composite hemostatic with a Janus structure, and belongs to the technical field of biomedical materials, the chitosan-based high-efficiency composite hemostatic mainly comprises methacrylic anhydride, chitosan, calcium carbonate and protonated acid salt, and the hemostatic is prepared by the following method: preparing methacrylic acid chitosan; the preparation method comprises the following steps: mixing modified chitosan with calcium carbonate, a photoinitiator and the like, dropwise adding the mixture into a carboxylated chitosan aqueous solution to form hydrogel microspheres with a shell structure, and carrying out photo-crosslinking, ion exchange, freeze drying and other methods to obtain Janus chitosan / calcium carbonate particles. And then mixing with protonated acid salt powder to obtain the chitosan-based efficient hemostatic with directional propulsion and a Janus structure. The high-efficiency composite hemostatic has the effects of driving property, water absorption and endogenous blood coagulation mechanism activation, and can be used for rapid hemostasis of irregular wounds.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and more particularly relates to a chitosan-based high-efficiency composite hemostatic agent with Janus structure and a preparation method thereof. Background technique [0002] Traumatic hemorrhage is one of the main causes of high mortality in patients. If the fatal hemorrhage is effectively stopped within 30 minutes, the survival rate of the injured can reach 85%. Efficient hemostatic materials can effectively control the degree of wound bleeding, reduce the bleeding time, reduce the amount of bleeding, prevent the wound from contacting the outside world and cause infection, and at the same time play a role in alleviating the pain of the patient, which is beneficial to the follow-up treatment and the wound healing of the patient. The traditional method of hemostasis mainly attaches bandages, tourniquets, etc. to the wound surface, and accelerates the hemostasis of the wound surface through ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/0094A61L24/0089A61L24/0036A61L24/0042A61L2300/102A61L2300/418A61L2300/412A61L2300/622C08L5/08
Inventor 于乔秦政杨钦博陈珊珊常凯曦邓宁越张竹韵赵伟锋苏白海
Owner SICHUAN UNIV
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