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A composite hemostatic repair material and its preparation method

A technology of repair materials and composite materials, which is applied in the field of composite hemostatic repair materials and its preparation, can solve problems such as limited hemostatic effect, harsh required conditions, and complicated preparation process, and achieves simple and easy-to-operate preparation methods, strong liquid absorption performance, The effect of promoting metabolism

Active Publication Date: 2022-03-15
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] CN102605459A discloses a tourmaline / chitosan composite material and a preparation method thereof. Using tourmaline and chitosan as raw materials, tourmaline particles are dispersed in the chitosan fiber matrix by stirring dispersion and electrospinning. Very limited hemostatic effect
Sun Rongzhan used shells and chitosan as raw materials to prepare shell powder / chitosan composite hemostatic repair materials through supercritical flow foam technology. Hemostatic experiments using animal models in vivo obtained good hemostatic effects. The preparation process is relatively complicated and the conditions required are harsh, so it is difficult to be popularized

Method used

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  • A composite hemostatic repair material and its preparation method
  • A composite hemostatic repair material and its preparation method
  • A composite hemostatic repair material and its preparation method

Examples

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Embodiment 1

[0037] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0038] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=8:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0039] (3) Pour the above mixture into a 100ml hydrotherma...

Embodiment 2

[0047] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0048] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=2:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0049] (3) Pour the above mixture into a 100ml hydrotherma...

Embodiment 3

[0053] (1) Wash the natural clam shells with deionized water and crush them, put the shell fragments in a pulverizer for 5 minutes, pass the obtained shell powder through a 200-mesh sieve, and then calcinate the shell powder in a muffle furnace at 300 °C 2h, that is, the required shell powder raw material is obtained;

[0054] (2) Take 1.584g of ammonium hydrogen phosphate and dissolve it in 50ml of deionized water, add 2.000g of shell powder under stirring conditions, then add tourmaline powder in the ratio of shell:tourmaline=8:1, adjust pH=9 with ammonia water, room temperature Stir for 1 hour under the same conditions, then sonicate for 0.5 hours, and stir again for 1 hour; the particle size range of tourmaline particles used is 1-10 μm, and micron-sized tourmaline needs to be mixed with deionized water and then ultrasonically dispersed to reduce agglomeration. Add tourmaline dispersion directly during stirring;

[0055] (3) Pour the above mixture into a 100ml hydrotherma...

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Abstract

The invention relates to a composite hemostatic repair material and a preparation method thereof. The hemostatic repair material uses shells and tourmaline as main raw materials, transforms shells and phosphorus sources into hydroxyapatite, and uses chitosan sponge as a matrix for loading . The preparation method uses shells and tourmaline as main raw materials, and uses ammonium hydrogen phosphate as a phosphorus source for hydrothermal reaction. The self-electric field on the surface of tourmaline has an attraction effect on charged ions in the system. The shell / tourmaline composite material is obtained by in-situ growth on the surface of the stone, and then the shell / tourmaline composite material is embedded in the chitosan sponge matrix through a freeze-drying process to prepare the shell / tourmaline composite hemostatic repair material. The hemostatic repair material can significantly shorten the coagulation time and achieve a good hemostatic effect.

Description

technical field [0001] The invention relates to the technical field of hemostatic repair materials, in particular to a composite hemostatic repair material and a preparation method thereof. Background technique [0002] For a long time, blood loss has been a great threat to people's life safety. According to statistics, the annual hemorrhagic shock death accounts for 30%-40% of traumatic injury deaths. In an emergency, it is very important to be able to achieve rapid hemostasis, and the hemostatic mechanism of the human body is a relatively complicated and time-consuming process. In some severe traumas, it is difficult to complete hemostasis only relying on the body's own hemostatic function At this time, it is necessary to apply external intervention to the wound to achieve the purpose of rapid hemostasis. Therefore, the development of high-efficiency hemostatic materials has become the key to rapid hemostasis and reduction of bleeding mortality. However, there are very f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/02A61L24/00
CPCA61L24/0084A61L24/0089A61L24/0005A61L24/0036A61L2400/04A61L2300/102A61L2300/418C08L5/08
Inventor 孟军平郭涛梁金生
Owner HEBEI UNIV OF TECH
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