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Hydrogel powder for rapid hemostasis and preparation method and application thereof
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A hydrogel and powder technology, applied in application, medical science, surgery, etc., can solve the problems of poor adhesion of hemostatic materials and achieve the effect of simple operation
Pending Publication Date: 2022-07-22
HUAZHONG UNIV OF SCI & TECH
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[0005] In view of the above defects or improvement needs of the prior art, the purpose of the present invention is to provide a rapid hemostasis hydrogel powder and its preparation method and application, wherein the detailed composition of the hydrogel powder, the corresponding hemostatic mechanism, etc. are improved , and optimize the control of the preparation method, using the polyacrylic acid hydrogel component grafted with N-hydroxysuccinimide ester (in the polyacrylic hydrogel component, except for the grafted part, the main body is polyacrylic acid hydrogel, polyacrylamide hydrogel or polyN-isopropylacrylamide hydrogel), and chi
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Embodiment 1
[0040] (1) At room temperature, dissolve 4g of chitosan in 100ml of water, then add 30g of acrylic acid, overnight.
[0041] (2) Take 20 g of the above solution, add 0.01 g of methacrylic acid anhydride gelatin, 0.05 g of α-ketoglutaric acid, and 0.2 g of N-acryloyloxysuccinimide, and stir until transparent.
[0042] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.
[0043] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.
[0044] (5) The lyophilized samples were put into a grinding tank at 50 Hz, and ground for 1 min to obtain hemostatic powder.
Embodiment 2
[0046] (1) At room temperature, dissolve 4g of carboxyethyl chitosan in 100ml of water, and then add 30g of acrylic acid for overnight.
[0047] (2) Take 20 g of the above solution, add 0.01 g of methacrylic acid anhydride gelatin, 0.05 g of α-ketoglutaric acid, and 0.4 g of N-acryloyloxysuccinimide, and stir until transparent.
[0048] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.
[0049] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.
[0050] (5) The lyophilized samples were put into a grinding tank at 50 Hz, and ground for 1 min to obtain hemostatic powder.
Embodiment 3
[0052] (1) At room temperature, dissolve 2g of chitosan and 2g of carboxyethyl chitosan in 100ml of water, and then add 30g of acrylic acid for overnight.
[0053] (2) Take 20 g of the above solution, add 0.01 g of methacrylic acid anhydride gelatin, 0.05 g of α-ketoglutaric acid, and 0.4 g of N-acryloyloxysuccinimide, and stir until transparent.
[0054] (3) Pour into the mold of the acrylic plate and cross-link in the UV cross-linking box for 30min.
[0055] (4) Take out the sample and freeze-dry it with a vacuum freeze dryer.
[0056] (5) The lyophilized samples were put into a grinding tank at 50 Hz, and ground for 1 min to obtain hemostatic powder.
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Abstract
The invention belongs to the technical field of medical polymer materials, and discloses hydrogel powder for rapid hemostasis as well as a preparation method and application thereof, the hydrogel powder comprises a chitosan component and a polyacrylic acid hydrogel component; wherein the chitosan component is selected from chitosan, a chitosan derivative, cellulose, chitin, gelatin, hyaluronic acid and agar; the main body of the polyacrylic acid hydrogel component is polyacrylic acid hydrogel, polyacrylamide hydrogel or poly (N-isopropylacrylamide) hydrogel, and the polyacrylic acid hydrogel component is further grafted with N-hydroxysuccinimide ester. By improving the detailed composition, the corresponding hemostatic action mechanism and the like of the hydrogel powder and preferably controlling the preparation method, compared with the prior art, the problems that an existing hemostatic material is poor in adhesion effect, needs to be pressed to assist in hemostasis and the like can be effectively solved; the hemostatic powder is green, safe, good in biocompatibility, high in tissue adhesion and capable of rapidly stopping bleeding.
Description
technical field [0001] The invention belongs to the technical field of medical polymer materials, and more particularly, relates to a rapid hemostasis hydrogel powder and a preparation method and application thereof. Background technique [0002] Blood loss is the leading cause of death, and prompt treatment of wounds and rapid hemostasis is the key to saving lives. Existing hemostatic materials include gauze, medical sponge, hemostatic gel and hemostatic powder. Gauze and medical sponges promote the body's own coagulation by absorbing a large amount of liquid components in the blood, thereby increasing the concentration of coagulation factors in the wound. Existing gauze and medical sponges are also based on polysaccharides, and chitosan or cellulose can promote red blood cell and platelet aggregation to accelerate hemostasis. However, gauze and medical sponge cannot form adhesion with biological tissues, so they all need to be pressed to assist hemostasis. This is not su...
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