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Application of folium mori total alkaloids in preparation of medicine for preventing and treating cerebral ischemia injury

A technology of total alkaloids and cerebral ischemia, which can be applied in the fields of drug combination, pharmaceutical formulation, food science, etc.

Active Publication Date: 2022-07-29
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although mulberry leaves have been used as traditional Chinese medicine for a long time, there are no reports on the efficacy of mulberry leaves and their active parts of total alkaloids in alleviating cerebral ischemic injury

Method used

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  • Application of folium mori total alkaloids in preparation of medicine for preventing and treating cerebral ischemia injury
  • Application of folium mori total alkaloids in preparation of medicine for preventing and treating cerebral ischemia injury
  • Application of folium mori total alkaloids in preparation of medicine for preventing and treating cerebral ischemia injury

Examples

Experimental program
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Embodiment 1

[0032] 1. Extraction of total alkaloids from mulberry leaves

[0033] like figure 1 As shown, add ddH according to the material ratio (W / V=1:8) 2 O, heating and refluxing extraction, gauze filtration and suction filtration, repeated three times, combined filtrates, concentrated, dynamic adsorption loading (2BV / h) LSI-010 cation exchange column, 10-15BV ddH 2 After O elution until the effluent becomes neutral, 7-8BV 0.5mol / L ammonia water is eluted, the eluent is collected and concentrated, suction filtration, dynamic adsorption and loading (2BV / h) D941 anion exchange resin, and the unadsorbed part is collected , concentration, activated carbon adsorption, decolorization, concentration, freeze-drying, Rays salt colorimetry to detect the total alkaloid content, the alkaloid content reaches 52%.

[0034] 2. Qualitative and quantitative detection of total alkaloids in mulberry leaves

[0035] Qualitative detection (thin layer chromatography): DNJ was used as a reference substan...

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Abstract

The invention relates to novel application of mulberry leaf extract, in particular to application of mulberry leaf total alkaloids in preparation of drugs for preventing and treating cerebral ischemia injury. The mulberry leaf total alkaloid can be used as an effective component to be applied to a medicine for preventing and treating cerebral ischemic stroke, and the new application of mulberry leaves is expanded. A new choice is provided for preventing and treating cerebral ischemic stroke; specifically, the invention relates to application of mulberry leaf total alkaloids in drugs for preventing and treating cerebral ischemic stroke. The invention relates to application of mulberry leaf total alkaloids in medicines for preventing and treating cerebral ischemic diseases. The invention discloses application of mulberry leaf total alkaloids in preparation of drugs for preventing and treating cerebral hypoxia fatigue. The invention relates to application in preparation of medicines for preventing and treating myocardial ischemia diseases.

Description

technical field [0001] The invention relates to a new use of mulberry leaf extracts, in particular to the application of total alkaloids of mulberry leaves in the preparation of medicines for preventing and treating cerebral ischemia injury. Background technique [0002] Mulberry leaves are the leaves of Morus alba L., a deciduous tree plant of the Moraceae family. It has the functions of dispersing wind-cold, clearing lung and moistening dryness, calming liver and improving eyesight. Although mulberry leaf has a long history of use as a traditional Chinese medicine, there is no report on the efficacy of mulberry leaf and its total alkaloid effective parts in reducing cerebral ischemia injury. Our previous studies have confirmed that total alkaloids are obtained by extracting and purifying mulberry leaves. The overall animal experiments have confirmed that preventive administration of total alkaloids from mulberry leaves can effectively reduce cerebral ischemia injury. SU...

Claims

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Application Information

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IPC IPC(8): A61K36/605A61P9/10A61P25/00A23L33/105A61K127/00
CPCA61K36/605A61P9/10A61P25/00A23L33/105A61K2236/331A61K2236/39A61K2236/55A61K2236/51Y02A50/30
Inventor 陈刚领
Owner CHINA PHARM UNIV
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