Application of Beclin1 as mammal intestinal homeostasis protective agent
A 1.beclin1, mammalian technology, applied in the field of biomedicine, can solve problems such as increased expression, and achieve the effect of protecting health
Pending Publication Date: 2022-07-29
苏天生命科技(苏州)有限公司
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Problems solved by technology
Studies have shown that the expression of Beclin1 is increased in colorectal cancer, but the role of Beclin1 in maintaining intestinal homeostasis has not been reported so far
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[0037] In order to make the above objects, features and advantages of the present invention more clearly understood, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without departing from the connotation of the present invention. Therefore, the present invention is not limited by the specific embodiments disclosed below.
[0038] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terms used herein in the description of the present invention are for the purpo...
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The invention discloses an application of Beclin1 as a mammal intestinal homeostasis protective agent. According to the application disclosed by the invention, by constructing an intestinal epithelium specificity Beclin1 deleted mouse, after the Beclin1 intestinal epithelium specificity is deleted, the intestinal tissue structure of the mouse is obviously abnormal, and the intestinal epithelium is damaged; according to the present invention, the mouse intestinal flora analysis results show that the homozygous deletion mouse intestinal flora changes significantly, and harmful bacteria related to gastrointestinal diseases increase, such that the Beclin1 is closely related to the mouse intestinal epithelium and the intestinal flora homeostasis maintenance; therefore, the Beclin1 disclosed by the invention can be used for preparing the mammal intestinal tract tissue and intestinal tract flora steady state protective agent to maintain the mammal intestinal tract tissue and intestinal tract flora steady state, and in the future, the steady state of the intestinal tract tissue and intestinal tract flora can be maintained by targeting the Beclin1, so that the health of a body is protected, and the Beclin1 is of great significance.
Description
technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of Beclin1, in particular to the application of Beclin1 as a mammalian intestinal homeostasis protector. Background technique [0002] Beclin1 is a 60-KDa coiled-coil protein originally discovered as a protein that binds to the anti-apoptotic protein Bcl-2. Subsequently, Beclin1 was found to be the autophagy homolog of yeast atg6 / vps30 in mammals, which plays an important role in autophagy and tumorigenesis. Since Beclin1 was discovered, as a star protein, the current research on it is still mainly focused on autophagy. Beclin1 can form PI3KC3 complex with Atg14, UVRAG, VPS34, etc., in the process of autophagosome formation and autophagy initiation. play a key role in. At the same time, with the deepening of research, many proteins that bind to Beclin1 have also been excavated one by one, such as Bif-1, ATM, Huntingtin, Ambra1, etc., which indicates that Beclin1 is inv...
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IPC IPC(8): A61K38/17A61P1/00
CPCA61K38/1709A61P1/00
Inventor 王建荣袁娜魏雯
Owner 苏天生命科技(苏州)有限公司