Device and method for establishing multi-sphere tissue model
A tissue and spheroid technology, applied in the field of biomedicine, can solve the problems of multi-spherical tissue model damage, difficulty in realizing controllable construction of multi-spherical tissue models, and complicated operation process of 3D tissue model construction.
Pending Publication Date: 2022-08-02
SUN YAT SEN UNIV SHENZHEN +1
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Problems solved by technology
[0004] The present invention provides a device and method for establishing a multi-spherical tissue model, which is used to solve the problem that the construction operation process of an in vitro 3D tissue model is complicated, it is difficult to realize the controllable construction of a multi-spherical tissue model, and the obtained multi-spherical tissue model is easily destroyed question
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[0048] The technical solutions of the present application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present application, but not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of this application.
[0049] In the description of this application, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "inner", "outer", "both sides", etc. is based on The orientation or positional relationship shown in the drawings is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operat...
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The embodiment of the invention discloses a device and a method for establishing a multi-sphere tissue model, and the device for establishing the multi-sphere tissue model comprises a base, an objective table, a photo-thermoelectric microfluidic platform, a mobile platform, an optical assembly and a sample application needle. Wherein the objective table, the mobile platform, the optical assembly and the sample application needle can move in different directions, so that the sample application needle and the optical assembly can be controlled in a multi-dimensional manner to carry out sample application on the photo-thermoelectric micro-fluidic platform, and a multi-sphere tissue model can be assembled; transparent glass of the photo-thermoelectric micro-fluidic platform can be used for preparing gel liquid drops, and a graphene nanosheet layer with photo-thermal conversion capacity, a wafer layer with a pyroelectric effect and an optical assembly are combined to generate a photo-thermoelectric effect, so that the gel liquid drops are controlled by non-uniform force in a non-uniform electric field; the controllable non-contact construction of the multi-sphere tissue model with the 3D structure is realized, the operation is simple, and the obtained multi-sphere tissue model has higher biological activity.
Description
technical field [0001] The invention relates to the technical field of biomedicine, in particular to a device and method for establishing a multi-spheroid tissue model. Background technique [0002] Cells and tissues in the human body and animals are all 3D structures, and only using 2D cell culture or animal models to understand the formation, function and pathology of cells and tissues cannot achieve ideal results. Therefore, the establishment of in vitro 3D tissue models is a good method. Technical means to simulate the physiological environment in vivo are of great significance for the development of both tissue engineering and regenerative medicine, which not only provide model systems for experimental ideas and potential therapeutic interventions, but also may allow high-throughput in vitro human tissue. Drug screening, which facilitates the development and screening of new treatments. [0003] However, in the prior art, although there are various methods for establis...
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Login to View More IPC IPC(8): C12M1/42C12M1/00C12M3/00C12N5/00
CPCC12M21/08C12M33/02C12M41/46C12M23/22C12M25/16C12M31/00C12M23/52C12N5/0062C12N2513/00C12N2535/00
Inventor 黄璐董建沛周建华
Owner SUN YAT SEN UNIV SHENZHEN