Application of compound in preventing and/or treating ankylosing spondylitis and corresponding composition

A compound and hydrate technology, applied in the application of compounds in the prevention and/or treatment of ankylosing spondylitis and the field of corresponding compositions, can solve problems such as weakening the immune system

Pending Publication Date: 2022-08-02
努瓦米德公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, there is a risk of weakening the immune system, as well as substantial toxicity to the patient's vital organs, such as the liver and kidneys

Method used

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  • Application of compound in preventing and/or treating ankylosing spondylitis and corresponding composition
  • Application of compound in preventing and/or treating ankylosing spondylitis and corresponding composition
  • Application of compound in preventing and/or treating ankylosing spondylitis and corresponding composition

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Embodiment Construction

[0147] The present invention relates to compounds of formula (I) and / or compounds of formula (Ia) for use in the prevention and / or treatment of AS, and compositions comprising the same.

[0148] Nicotinamide adenine dinucleotide (NAD) is a coenzyme present in all living cells. NAD exists in cells in either the oxidized form NAD+ or the reduced form NADH. NAD functions as an electron transporter involved in metabolic redox reactions. NAD is also involved in many cellular processes, such as the ribosylation of ADP in post-translational protein modifications.

[0149] NAD can be synthesized de novo by cells from amino acids such as tryptophan or aspartate. However, this synthesis is trivial because the main synthetic pathway for NAD is the recycling pathway, by which cells, mainly the nucleus, recycle compounds to reform NAD from precursors. NAD precursors include nicotinic acid, nicotinamide riboside, nicotinamide mononucleotide, and nicotinamide.

[0150] NMN is one of the ...

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Abstract

The present invention relates to a compound of formula (I) and / or a compound of formula (Ia) for use in the prevention and / or treatment of ankylosing spondylitis, as well as to compositions and formulations comprising parallel forms of said compounds.

Description

technical field [0001] The present invention relates to the use of compounds of formula (I) or (Ia) and compositions comprising them for the treatment and / or prevention of ankylosing spondylitis. Background technique [0002] A joint is the assembly: specifically the assembly of the two cartilage-covered ends of the bone, and the synovium that wraps this assembly. The role of the synovium is to facilitate joint movement by secreting a lubricant: synovial fluid. Inflammatory rheumatic diseases include, inter alia, inflammation of the synovium. Excess synovial fluid is then secreted and the synovium thickens abnormally. The soft tissue and bony surfaces of the joint are subsequently damaged. The joints become unusually swollen and painful, hindering movement. [0003] Ankylosing spondylitis, an inflammatory rheumatic disease that most commonly affects the spine, pelvis and sacrum, describes a form of the disease known as the "axial" form. The "peripheral" form affects joi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K45/06A61P29/02A01K67/027
CPCA61K31/706A61K45/06A61P29/02A01K2267/0368A61K2300/00A61P19/02A61K9/0019A61K9/0051A61K9/0073C07D401/10C07D401/14C07D405/14C07D409/14C07D421/14
Inventor G·伯蒙德L·加康
Owner 努瓦米德公司
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