System for preparing gel beads

Abstract

A system for preapring gel beads its composed of raw material tank with temp. controller and stirrer, delivering unit consisting of creep pump and rubber pipe, and microdrop preparing unit consisting of multi-nozzle sprayer, drop generator and gelatinizing container. Its advantages are uniform gel beads, adjustable output rate and continuous production.

Description

technical field [0001] The present invention relates to a preparation system for producing gel beads. Background technique [0002] As an immune isolation tool for tissue cell transplantation to treat neurological / endocrine diseases, a delivery tool for gene therapy, a new dosage form for drug controlled release, and a cell culture carrier for the production of specific products, microcapsules are very important in the fields of biology, medicine, pharmaceuticals, and bioengineering. role. One of the means of controlling the performance of the above microcapsules is the preparation of gel beads, which determine the specifications, particle size, particle size distribution, symmetry and other properties of the prepared microcapsules. With the application of microcapsules in various fields With the development of research, the need for large-scale preparation technology of high-quality gel beads is becoming more and more significant. However, the production rate of the curre...

AI Technical Summary

Problems solved by technology

However, the production rate of the current gel bead preparation system is extremely low. For example, the hydrogel liquid and the embedded material are mixed in a syringe, and driven by the syringe pump, a droplet is formed at the tip of the needle, which is generated by a droplet generator. The controllable high-frequency alternating electric field pulls the droplet to form a controllable micro-droplet (150-2000μm), which is dripped into the coagulation solution to form a gel bead, and then the gel bead is formed into a microcapsule through a series of chemical reactions such as film formation

In addition, the storage tank of the existing preparation system has no temperature control protection, the bacteria can only survive for about 40 minutes, and other active substances are easily lost; without a stirring device, it is difficult to maintain evenly dispersed embedded materials such as cells. Under this condition, the cell deposition time 20 minutes is not conducive to film formation and maintaining a suitable embedding volume; the plunger rod of the syringe is used to push, and the treatment volume at one time is less than 40mL, and the material cannot be continuously conveyed; single needle produces droplets, and the production rate is less than 60mL / h

Therefore, the existing preparation system is not suitable for large-scale and continuous production, and cannot meet the needs of industrial production.

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