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Use of Chinese medicinal palmatine hydrochloride in treatment of diabetes II

A technology of palmatine hydrochloride and extract, which is applied in the field of ingredients of traditional Chinese medicine raw materials, and can solve problems such as excessive dosage of sulfonylurea drugs and hypoglycemia

Inactive Publication Date: 2006-08-30
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] An obvious side effect of sulfonylureas is hypoglycemia when the dose is too large

Method used

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Embodiment Construction

[0025] The following is a further detailed description about the specific implementation and therapeutic effects of the present invention given by the inventor in conjunction with preferred embodiments.

[0026] 1. Extraction of effective parts of Coptidis Rhizoma and Phellodendron Phellodendri

[0027] Coptidis Rhizoma or Phellodendron Phellodendri was heated and refluxed twice with 85% ethanol in an amount of 8 times, each time for 2 hours. Combine the extracts, recover ethanol, and concentrate the water to make it viscous. Add 1 / 2 of the amount of medicinal materials in water, stir, filter with multi-layer gauze, and add an appropriate amount of Ca(OH) to the filtrate 2 , stirred, let stand for 24h, and filtered. Concentrate the filtrate, let it cool, adjust pH 1 to pH 2 with hydrochloric acid, let it stand still, there is precipitation, filter, dry the precipitation to obtain Phellodendron Phellodendri or Coptidis Rhizoma extract.

[0028] 2. TLC Qualitative Analysis of C...

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Abstract

An application of the palmatine hydrochloride extracted from coptis root or phellodendron bark for treating diabetes B is disclosed.

Description

technical field [0001] The invention relates to a composition derived from raw materials of traditional Chinese medicines, in particular to a composition of palmatine hydrochloride derived from extracts of raw materials of Coptidis Rhizoma and Phellodendron Phellodendri. The invention also relates to the application of the palmatine hydrochloride in the extract in the preparation of medicines for treating type II diabetes. Background technique [0002] Diabetes mellitus (DM) is a clinical syndrome caused by the interaction of genetic and environmental factors, and is one of the most common endocrine diseases. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissues to insulin lead to a series of metabolic disorders of sugar, protein, fat, water and electrolytes. Clinically, three excesses (polyphagia, polydipsia, polyuria), one deficiency (weight loss), and hyperglycemia symptoms appear. According to diff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4745A61P3/10
Inventor 杨广德贺浪冲李西玲赵良
Owner XI AN JIAOTONG UNIV
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