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Method for preparing hepatitis treating medicine and the product produced thereby

A technology for medicine and liver disease, applied in the production of hepatitis therapeutic drugs and their products, can solve the problems of inactivation of active substances and limited effect of drugs

Active Publication Date: 2006-12-20
BELX BIO PHARMA (TAIWAN) CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as mentioned above, the effect of traditional oral decoction is limited, and the extraction step is often carried out in industry with toxic organic solvents, and the process often deactivates the active substance

Method used

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  • Method for preparing hepatitis treating medicine and the product produced thereby
  • Method for preparing hepatitis treating medicine and the product produced thereby
  • Method for preparing hepatitis treating medicine and the product produced thereby

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The preparation of embodiment 1, mountain ramie extract--JM

[0039] First take 0.36 kg of ramie root, add 3.6 kg of water, and soak for 2 hours. Then decoct at 100°C for about two hours, and then filter to obtain a decoction. Add 2.2 kg of water to the medicinal materials, decoct at 100°C for about two hours, and then filter to obtain another decoction. The two decoction filtrates were mixed, then concentrated under reduced pressure to 0.218kg, and the measured solid content was 15.3%. A total of 33 g of the product JM was obtained after freeze-drying.

Embodiment 2

[0040] Embodiment 2, the preparation of ramie extract--BMEC-1

[0041] Take 15 kg of ramie roots, add 150 kg of water, and soak for 8-16 hours. After decocting at 100°C for two hours, filter to obtain a decoction filtrate. Then add 150 kg of water to the medicinal materials, decoct at 100°C for two hours, and filter to obtain the second decoction filtrate. Then the above two decoction filtrates were combined to obtain 266 kg of decoction, which was then concentrated under reduced pressure to 8.3 kg, and the solid content rate was recorded to be 17.6%. Stir the concentrate and add 15 L of 95% ethanol for alcohol precipitation using a peristaltic pump. Finally, a centrifuge was used to separate the alcohol precipitation solution, and the supernatant was collected, concentrated under reduced pressure, and freeze-dried to obtain the product BMEC-1, a total of 1.013 kg.

Embodiment 3

[0042] Embodiment 3, the preparation of ramie extract--BMEC-101

[0043]First take 95 kg of ramie roots, add 800 kg of water, and soak for 8 to 16 hours. After decocting at 100°C for 2 hours, filter to obtain the first decoction filtrate; then add 700 kg of water to the medicinal materials, and then decoct at 100°C for 2 hours, filter to obtain the second decoction filtrate; combine the first decoction filtrate and the second decoction filtrate to obtain Decoction 1340kg, then concentrated under reduced pressure to 42kg (the first concentrated solution), the solid content rate was measured to be 25%; then the concentrated solution was stirred and 70L of 95% ethanol was added using a peristaltic pump for alcohol precipitation; using a centrifuge Centrifuge the alcohol precipitate, collect the supernatant, concentrate under reduced pressure to 12.5kg (the second concentrated solution), and record a solid content rate of 15%; then the second concentrated solution is centrifuged t...

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Abstract

The invention relates to a method for preparing hepatitis treating medicine and the product produced thereby, wherein the method consists of disintegrating the plants, soaking with water, grilling into water raffinate, concentrating the water raffinate into a first concentration liquid, charging ethanol to obtain precipitate, concentrating the liquid phase layer into a second concentration liquid and drying, flowing the second condensation liquid through resin tower, extracting with water, water / ethanol miscible liquid and ethanol, collecting the raffinate, mixing and concentrating the raffinate into a third concentration liquid, and finally drying.

Description

technical field [0001] The present invention relates to a production method and its products for treating hepatitis, especially a medicinal composition for treating liver diseases and a preparation method thereof, especially a medicinal composition using ramie plants for treating liver diseases and its preparation method. Background technique [0002] Chronic liver disease (chronic hepatitis, liver cirrhosis and liver cancer) is the natural enemy of human health. Liver disease can be divided into viral liver disease, alcoholic liver disease, drug or toxic liver disease and metabolic abnormal liver disease according to its etiology. There are currently about 350 million people in the world who are carriers of chronic hepatitis B, and 2.7 million people are patients with chronic hepatitis C. In Taiwan, liver disease is also quite rampant. The carrier rate of hepatitis B is about 15-20%, and 2-4% of the population in Taiwan is also infected with hepatitis C virus. Therefore, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/48A61P1/16A61P31/12
Inventor 潘一红谢右铭黄志杰邱惜禾朱朝庭吕居勋蔡佩宜范玮伦彭文煌谢明村
Owner BELX BIO PHARMA (TAIWAN) CORP