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Method, apparatus and compositions for inhibiting the human scent tracking ability of mosquitoes in environmentally defined three dimension spaces

A composition and environmental technology, applied in the fields of botanical equipment and methods, biocides, animal repellants, etc., can solve problems such as not being very effective

Inactive Publication Date: 2007-03-21
BIOSENSOR INC +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since most repellents have only limited repellency and are often not very effective, there are not many examples of successful development of more effective repellents

Method used

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  • Method, apparatus and compositions for inhibiting the human scent tracking ability of mosquitoes in environmentally defined three dimension spaces
  • Method, apparatus and compositions for inhibiting the human scent tracking ability of mosquitoes in environmentally defined three dimension spaces
  • Method, apparatus and compositions for inhibiting the human scent tracking ability of mosquitoes in environmentally defined three dimension spaces

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The three-cage and two-mouth odor analyzer described and described in "Journal of Medical Entomology" [J.Med.Entomol.], 35(3), 330-334(1998) by Posey et al. was used to study 6-8 Reaction of day-old laboratory-bred adult female Aedes aegypti. This system allows mosquitoes to choose between two different stimuli. The odor tester is made of transparent acrylic plastic and contains three test chambers in a layered configuration, each with a pair of movable sleeves and mosquito traps. The instrument is equipped with a filtered external air supply system, which can accurately control temperature (+ / -0.5°C) and relative humidity (+ / -2%). Only one room is used for testing at a time. Before entering the selection port, mosquito trap and odor detector, the outside air must pass through a series of carbon filters and, if necessary, be heated and humidified for air conditioning.

[0025] One hour before the start of the experiment, approximately 75 female Aedes aegypti mosquitoes were...

Embodiment 2

[0031] The test compound was used together with the synthetic human odor attractant, and the experiment was carried out similar to that described in Example 1. The combination of experiments is as follows:

[0032] (1) CS vs. CS (comparison)

[0033] (2) Dehydrolinalool + CS vs. CS

[0034] (3) Linalool + CS vs. CS

[0035] For comparison, the well-known tropical mosquito repellent, DEET-N,N-dihexyl-3-methylbenzamide is used as a control for dehydrolinalool and linalool. The test concentration of each compound is 100, 250 and 500 μl, respectively. The results are listed in Tables 2, 3, and 4. The data in the table is still expressed in terms of the percentage of mosquitoes attracted to mouth 1 or 2, and the percentage of mosquitoes that were not attracted to mouth 1 or 2.

[0036] Test compound and dosage

[0037] Test compound and dosage

[0038] Test compound and dosage

Embodiment 3

[0040] In the further inhibitory ability test of the compound of the present invention, the following field test was carried out using linalool as an inhibitor. The experiment was set up in Sarasota, Florida, and the experiment site was adjacent to the wetland breeding area where the forest was planted. 200ml / min CO for trap 2 As a bait, it is equivalent to the breath of a person weighing 91 kg (2001b). As an experimental control, it is used continuously every night. In the collection of the trap, the mosquito population is counted first, and then the type of mosquito is checked. About 91% of the mosquito population are Culex nigripalpus. In Florida, it is the vector of St. Louis encephalitis.

[0041] The experimental design uses a 2×2 Latin square. The experiment was carried out in two open areas separated by 24 meters (80 ft), marked as positions 1 and 2, respectively. Each area is 2.4 meters × 2.4 meters (8ft × 8ft), which is 5.76 square meters (64ft 2 ). The wooden pillars ar...

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PUM

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Abstract

Composition for inhibiting the ability of mosquitoes to locate a target by olfactory emissions of the target comprise a composition of at least one inhibiting compound selected from the group consisting of 3-methyl-1-alkene-3-ols of the formula: and 3-methyl-1-alkyn-3-ols of the formula: wherein R1 and R2 are each independently a saturated or unsaturated aliphatic hydrocarbon group containing from 1 to about 12 carbon atoms.

Description

Invention field [0001] The present invention relates to a method, apparatus and composition for inhibiting the ability of mosquitoes to find or track the human body through odor detection. More specifically, the present invention relates to certain compounds used in compositions and devices to inhibit the ability of mosquitoes to detect humans through odor. Background of the invention [0002] The use of compounds, compositions and formulations to protect humans from mosquito bites is known in the art. Generally speaking, these compounds, compositions and preparations have the ability to stay on human skin for a period of time after topical or topical application to repel mosquitoes. Many kinds of auxiliary materials have been added to the mosquito repellent to increase the retention of the repellent on human skin. However, although many attempts have been made to improve the repellent activity of existing mosquito repellents, none of them succeeded. Almost eve...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N27/00A01P7/00A01N31/02A01N49/00
CPCA01N31/02A01N49/00
Inventor J·A·诺仁R·H·贝多吉恩R·E·马洛尼D·L·克林
Owner BIOSENSOR INC
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