4-oxo-4,7-dihydro-thieno [2,3-b] pyridine-5-carboxamides as antiviral agent

Abstract

The invention provides a compound of formula (I), wherein R<1>, R<2>, R<3>, and R<4> have any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.

Description

field of invention

[0001] The present invention provides 4-oxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxamide derivatives, more precisely provides formula (I) 5-benzylaminocarbonyl - 4-oxo-4,7-dihydro-thieno[2,3-b]pyridine derivatives, which are useful as antiviral agents (for example as antiherpes virus agents). Background of the invention

[0002] Herpes viruses include a large group of double-stranded DNA viruses. They are also the source of the most common viral diseases in humans. Eight herpesviruses have been shown to infect humans: herpes simplex virus types 1 and 2 (HSV-1 and HSV-2), varicella zoster virus (VZV), human cytomegalovirus (HCMV), Epstein-Barr virus (EBV) , and human herpesvirus types 6, 7, and 8 (HHV-6, HHV-7, and HHV-8).

[0003] HSV-1 and HSV-2 cause herpetic lesions on the lips and genitals, respectively. They also occasionally cause eye infections and encephalitis. HCMV can cause birth defects in newborns and may tri...

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