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HCV combination therapy containing ribavirin in association with antioxidants

An anti-oxidant, ribavirin technology, applied in the field of pharmaceuticals to improve ribavirin-related hemolysis, can solve the problem of reducing

Inactive Publication Date: 2002-06-26
SCHERING AG
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] However, this combination therapy is not always effective due to concomitant ribavirin side effects such as ribavirin-related hemolysis (measured by decreased hemoglobin concentration)

Method used

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Embodiment Construction

[0016] The present invention provides methods and pharmaceutical compositions for treating susceptible viral infections, especially hepatitis C virus infections.

[0017] The term "susceptible viral infection" as used herein means a viral infection caused by a wide range of RNA and DNA viruses, including but not limited to virus families, such as the flavirus genus including flaviviruses and Kuning virus It is a member of pestivirus (pestivirus), hepatitis virus (hepavirus) of which hepatitis C virus is a member, and arbovirus, orthomyxovirus, and paramyxovirus of which West Nile virus is a member , Arena virus, Bunyang virus, herpes virus, adenovirus, pox virus and retrovirus.

[0018] Typical suitable "susceptible viral infections" include influenza A and B virus infections, parainfluenza virus infections, respiratory syncytial virus ("RSV") infections such as RSV bronchiolitis and RSV pneumonia, especially RSV infections in infants and young children and previous RSV pneumonia,...

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Abstract

Methods of treating patients having susceptible viral infections, especially chronic hepatitis C infection by administering to said patient a thereapeutically effective amount of a combination therapy of interferon-alfa and ribavirin for a time sufficient to lower HCV-RNA in association with a therapeutically effective amount of an antioxidant for a time sufficient to ameliorate ribavirin-related hemolysis are disclosed.

Description

Background of the invention [0001] The present invention relates to the preparation of a medicament for improving ribavirin-related hemolysis by using antioxidants, and the hemolysis is related to the treatment of susceptible viral infections with ribavirin. [0002] The treatment of patients who are susceptible to viral infections, especially chronic hepatitis C virus infections, includes administering to the patient a therapeutically effective amount of a-interferon and ribavirin combined therapy, the course of which is sufficient to reduce HCV-RNA, and at the same time A therapeutically effective amount of antioxidants is given, and the course of treatment is sufficient to improve ribavirin-related hemolysis. [0003] Chronic hepatitis C virus infection is a particularly insidious and slowly progressing viral disease that has a significant impact on the quality of life. It can eventually lead to liver cirrhosis, decompensated liver disease and / or hepatocellular carcinoma. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/01A61K31/05A61K31/07A61K31/10A61K31/122A61K31/198A61K31/355A61K31/375A61K31/7056A61K33/04A61K38/21A61P7/06A61P31/00A61P31/12A61P39/06A61P43/00
CPCA61K38/212A61P31/00A61P31/12A61P39/06A61P43/00A61P7/06A61K31/70A61K31/355A61K2300/00
Inventor C·A·布拉斯P·W·格吕E·皮肯
Owner SCHERING AG
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