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Biological reactor

A bioreactor and tank technology, applied in bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, biochemical equipment, etc., can solve the problem of bacteria entering the reactor and the seal of the shaft seal is not tight , contamination of cultures and other issues, to achieve the effect of convenient bearing installation, convenient maintenance, and not easy to infect bacteria

Inactive Publication Date: 2003-01-22
HUAZHONG UNIV OF SCI & TECH
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Problems solved by technology

Therefore, long-term use will cause the sealing of the shaft seal to be loose due to wear and tear, and it is easy for bacteria to enter the reactor and contaminate the culture.

Method used

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  • Biological reactor
  • Biological reactor
  • Biological reactor

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with drawings and embodiments.

[0016] Such as figure 1 As shown, the magnetic coupling transmission stirring bioreactor is mainly composed of motor shaft 1, outer magnetic cylinder 2, shaft top cover 3, inner magnetic cylinder 4, inner magnetic cylinder fixing bolt 7, reactor upper cover plate 8, stirring shaft 9, Bearing box fixing plate 11, air inlet pipe 14, flange 15, glass outer wall 16, temperature sensor jack 17, jacket 18, pull rod 19, discharge pipe 20 and stirring paddle 21 constitute. Wherein, it should be emphasized that a certain gap should be reserved around the stirring shaft 9 in the center of the reactor top cover plate 8, and a certain gap should be left between the bearing box fixing plate 11 and the reactor top cover plate 8, so that During sterilization, high-pressure steam can enter the shaft top cover 3 through the pores, thereby completely killing miscellaneous bacteria. Oth...

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Abstract

The bioreactor includes a cylinder and a transmission mechanism and has top cover to seal the cylinder, cup-shaped outer magnetic tank connected to the motor shaft, coaxial inner magnetic tank, stirring shaft with one end fixed to the inner tank and the other end extending beyond the top cover, and positioning bearing for the stirring shaft and inside a bearing box fixed to the top cover. Both the outer and inner magnetic tanks are made of permanent magnetic material while the outer parts of non-magnetic material. Compared with available technology, the present invention has the advantages ofsealed cylinder, complete sterilization, easy bearing installation etc.

Description

technical field [0001] The invention relates to a bioreactor, which is a bioreactor which uses magnetic coupling to drive a stirring shaft to rotate. Background technique [0002] At present, bioreactors are widely used in the fields of animal and plant cell culture and microbial fermentation, and are the core production equipment of the biotechnology industry. In the process of large-scale cultivation of bioreactors, bacterial contamination is a very serious problem, which often leads to the pollution and scrapping of the entire bioreactor culture and raw materials, resulting in huge economic losses. The stirring device of the existing bioreactor needs the contact connection between the stirring shaft and the motor outside the tank to transmit the mechanical movement. "Special Mechanical Seals for Fermentation Tanks". Therefore, long-term use will cause the seal to be loose due to wear and tear, and it is easy for bacteria to enter the reactor and contaminate the culture....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/02
CPCC12M27/08C12M23/34C12M23/20
Inventor 余龙江薛勇
Owner HUAZHONG UNIV OF SCI & TECH
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