Etomidate fatty emulsion injection preparation method

A technology of etomidate and emulsion injection, which is applied in the field of pharmaceutical fat emulsion injection preparations, can solve the problems of restricting the production and application of preparations, high cost, complicated process, etc., and achieve the effects of low cost, short time and simple preparation method

Inactive Publication Date: 2003-03-05
NHWA PHARMA CORPORATION
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method of etomidate fat emulsion injection has complex processes, especially the high cost

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] Take the preparation of 1000 (20mg / 10ml) injections as an example:

[0014] Etomidate 20g

[0015] Long Chain Fatty Acid Triglycerides 1000g

[0016] (soybean oil for injection)

[0017] Egg Yolk Lecithin 120g

[0018] Glycerin 250g

[0019] Water for injection 10000 ml

[0020] Filter soybean oil and lecithin with microporous membrane respectively, put them into the container according to the above amount, then place the container in a water bath, heat to about 50°C, stir evenly, and make an oil phase; add etomidate into the oil phase, mixed evenly to obtain a mixed solution; put water for injection in another container, add glycerin, stir evenly and filter through a 0.45um microporous membrane to form a water phase; will contain etomidate, soybean oil and The mixed solution of lecithin is poured into the aqueous phase containing glycerin under high-speed stirring to make colostrum, and the pH is adjusted to weak alkalinity with 1M sodium h...

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Abstract

The preparation method of etomidiate aliphatic emulsion injection includes the following steps: placing soybean oil and lecithin into a container, heating, uniformly stirring them to obtain oil phase, adding etomidate into the oil phase to make them into mixture liquor; placing injection water into another container, adding glycerin, uniformly stirring them and filtering to obtain water phase; under the condition of high-speed stirring adding the above-mentioned mixture liquor into the water phase to obtain initial emulsion, regulating pH value, high-pressure homogenizing, filtering, filling into ampule, introducing nitrogen, sealing and sterilizing so as to obtain the invented product.

Description

technical field [0001] The invention relates to a pharmaceutical fat emulsion injection preparation, in particular to a preparation method of etomidate fat emulsion injection preparation. Background technique [0002] Etomidate is a non-barbiturate intravenous anesthesia inducer, its action strength is 4 times that of barbiturate sodium and 12 times that of thiopental sodium, and the induction of general anesthesia is fast, and the recovery and recovery after administration are also fast , After the patient wakes up, no drowsiness, dizziness and other adverse reactions will occur, and it has a certain anti-vomiting effect, so it has been widely used. Etomidate is available in water-soluble injections and fat emulsion injections. Due to the high injection osmotic pressure of water-soluble injections, side effects such as pain at the injection site, muscle tremor, postoperative phlebitis, and thrombophlebitis often occur; however, fat emulsion injections have no or reduced th...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61P25/20
Inventor 陈亮马彦琴郑世君王金刚
Owner NHWA PHARMA CORPORATION
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