Medicine for treating acute external affection heat disease and its preparing method
A technology for exogenous febrile diseases and medicines, applied in the field of preparation of the medicines, can solve the problems of slow onset, slow absorption, unfavorable treatment of acute diseases, etc.
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Embodiment 1
[0016] Take 4800g of Forsythia and 4800g of Houttuynia cordata, mix well, heat and reflux with 8 times of 75% ethanol for 2 times, 1 hour each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.05~1.15 (50 ℃), refrigerate, take the supernatant and extract 4 times with 4 times the amount of water-saturated n-butanol, combine the n-butanol solution, recover the n-butanol under reduced pressure, and dry the concentrated solution in vacuum at 65°C to obtain forsythia and Houttuynia cordata mixed extract. Take the above extract, add 2500ml of water, stir and dissolve, the solution is refrigerated at 4°C for 24 hours, the supernatant is filtered with a 0.45um filter membrane, the solution is concentrated under reduced pressure and vacuum dried at 65°C to obtain a dry paste. Dissolve the dry ointment with 2000ml of water for injection, add 45g of mannitol for injection, adjust the pH to 6.0-8.0 with 40% sodium hydroxide solu...
Embodiment 2
[0018] Take 5100g of Forsythia and 5100g of Houttuynia cordata, mix well, heat and reflux with 9 times 70% ethanol for 2 times for 1.5 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to a relative density of 1.05~1.15 (50 ℃), refrigerate, take the supernatant and extract 5 times with 6 times the amount of water-saturated n-butanol, combine the n-butanol solution, recover the n-butanol under reduced pressure, and dry the concentrated solution in vacuum at 65°C to obtain Forsythia and Houttuynia cordata mixed extract. Take the above extract, add 2500ml of water, stir and dissolve, the solution is refrigerated at 4°C for 24 hours, the supernatant is filtered with a 0.45um filter membrane, the solution is concentrated under reduced pressure and vacuum dried at 65°C to obtain a dry paste. Dissolve the dry paste with 2000ml water for injection, add 50g of mannitol for injection, adjust the pH to 6.0-8.0 with 40% sodium hydroxide solutio...
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