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Lipoidosis of Chinese herbal medicine alkaloid and its preparation

A technology of alkaloids and liposomes, applied in the field of medicine, can solve the problems of poor absorption and difficult to reach the blood concentration of tumor cells.

Inactive Publication Date: 2003-10-08
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In anti-tumor experiments, Huang Linqing and others found that the anti-tumor effect of Ber in vivo is not as obvious as that in vitro, and it may be poorly absorbed by the intestinal tract, and it is difficult to reach the effective plasma concentration of Ber in the body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Example 1: Preparation of Berberine Liposomes

[0045] prescription:

[0046] Berberine 0.2g

[0047] Soy Lecithin 2g

[0048] Amount of ethanol

[0049] Make 50ml

[0050] Preparation Process:

[0051] Prepared according to the "active drug loading method". The encapsulation efficiency was 75.3%.

Embodiment 2

[0052] Example 2: Preparation of Berberamine Liposomes

[0053] prescription:

[0054] Berberamine 0.1g

[0055] Hydrogenated Soy Lecithin 1g

[0056] Amount of ethanol

[0057] Make 50ml

[0058] Preparation process: the same as "Example 1", the encapsulation rate is 81.3%.

Embodiment 3

[0059] Example 3: Preparation of sulfadiazine (Sencapine) liposomes

[0060] prescription:

[0061] Sencapine (Seraphine) 0.4g

[0062] Egg yolk lecithin 4g

[0063] Cholesterol 1g

[0064] Amount of ethanol

[0065] Make 100ml

[0066] Preparation process: the same as "Example 1", the encapsulation rate is 86.6%.

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PUM

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Abstract

A Chinese-medicinal alkaloid lipoid in the form of injection, orally applied medicine, syrup, drops, inhalation, or exteriorlly applied ointment for suppressing tumor contains Chinese-medicinal alkaloid (0.1-2 wt.%), phosphatide (lecithin, distearyl phosphatidylglycerol, etc). (0.5-10 wt.%) and cholesterol (0-5 wt.%). Its advantages are high active concentration in blood, and high curative effect.

Description

Technical field: [0001] The invention relates to the technical field of medicine, specifically, it relates to a traditional Chinese medicine alkaloid liposome and its preparation. Background technique: [0002] Liposomes are prepared by using phospholipids and said alkaloids (including: berberine, berberamine, serratine (seraphine), tetrahydropalmatine and patulin), which can be administered through veins, muscles, Oral, nasal and other routes of administration. [0003] Chinese medicine alkaloids are a class of compounds with strong physiological activity, such as berberine (berberine, Ber) is an isoquinoline alkaloid extracted from plants such as Coptis chinensis, which is effective against a variety of Gram-positive bacteria. It has bacteriostatic effect and negative bacteria, and is mainly used for clearing away heat and detoxification and treating intestinal infection in clinical practice. In recent years, it has been found that Ber has a variety of non-antibacterial ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/14A61K31/4375
Inventor 邓意辉王绍宁吴琼
Owner SHENYANG PHARMA UNIVERSITY
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