Use of timosaponin for preparing medicine for preventing and treating brain apoplexy
A technology of timothy saponins and total saponins, applied in the field of medicine, can solve the problems such as unseen total timothy saponins and the like
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[0011] The preparation method of the total saponins of Anemarrhena in the present invention is as follows: conventionally heat-extract the pulverized Anemarrhena medicinal material with 20-95% ethanol, and the amount of the solvent for the first time is about 4 to 8 times of the crude drug amount; or use 20 ~95% ethanol percolation extraction, solvent consumption is about 4~12 times of crude drug amount; The extract is concentrated, and the concentrate is centrifuged or filtered; The centrifugal supernatant or filtrate of the concentrate is absorbed by macroporous resin (macroporous resin is Polystyrene-type porous adsorption resin with styrene as bridging material, such as D101, D201, ZTC-1, AB-8, 1300-1 type macroporous resin, etc.), rinse with water and ethanol below 20% to remove Impurities; then eluted with water-containing lower alcohols, such as methanol, ethanol or propanol C 1 ~C 5 Alcohols, the concentration is 30-95%, the dosage is 5-15 times of the crude drug amou...
Embodiment 1
[0033] Example 1 Preparation of total timosaponins
[0034] Put 100 kg of pulverized anemarrhena medicinal materials into the extraction tank, heat-extract three times with 400 liters of 70% ethanol at 90-100 ° C, each extraction time is 90 minutes, combine the three extracts, concentrate to 80 liters, and filter , the filtrate was adjusted to 100 liters with distilled water. Then slowly pass through the adsorption column that 350 liters of ZTC-1 type macroporous resin (produced by Tianjin Zhengtiancheng Clarification Technology Co., Ltd.) is housed, remove impurities by eluting with 500 liters of distilled water and 1000 liters of 20% ethanol, and then use 1000 liters of 45% ethanol to remove impurities. Eluted with ethanol, collected the eluate, concentrated to dryness, dried and pulverized to obtain a yellow powder, which was the total saponins of Anemarrhena of the present invention, weighing 2.7 kg in total, and the yield was 2.7% based on crude drug amount.
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