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Purifying technology for lipid bufalin genin and cino-bufagin in fresh senso

A technology of repobufagenin and cinobufin-toxin, which is applied in the field of purification of repobufagenin and cinobufin-toxin from fresh toadswain

Inactive Publication Date: 2003-11-26
王利忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The active ingredients in fresh toad venom are redibufagenin and cinobufinin, which are important raw materials in pharmaceuticals. At present, there is no effective method to purify repobufagenin and cinobufinin with high purity from fresh toads. Toxic base

Method used

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Embodiment Construction

[0006] According to the purification technology of bufoginin and cinobufin in fresh toad venom according to the present invention, the purification method is as follows: after grinding 50 grams of fresh toad venom, add 500 milliliters of organic solvent ethanol with a purity of 70%-90%, and stir to obtain the toad venom solution, then place it statically for 2-3 hours, then filter the solution of toad venom after standing still, then distill the obtained filtrate to remove ethanol, and after freeze-drying, it is obtained Toad powder products with high content of lipobufagin and cinobufagin.

[0007] The organic solvent ethanol added above can also be replaced with ethyl acetate, or chloroform, or dichloromethane. The standing time of the toad venom solution can also be 3 to 8 hours.

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Abstract

The present invention discloses the technology of purifying lipid bufogenin and cino-bufogenin in fresh toad cake. The purifying process includes grinding fresh toad cake, adding organic solvent through stirring to obtain toad cake solution, standing, filtering to obtain filtrate, concentrating and drying to obtain the product. The toad cake powder product has relatively high lipid bufogenin and cino-bufogenin content.

Description

technical field [0001] The invention relates to a technique for extracting active ingredients from fresh toad's venom, in particular to a technique for purifying adipobufagenin and cinobufin base in fresh toad's venom. Background technique [0002] The active ingredients in fresh toad venom are redibufagenin and cinobufinin, which are important raw materials in pharmaceuticals. At present, there is no effective method to purify repobufagenin and cinobufinin with high purity from fresh toads. Toxic base. Contents of the invention [0003] The technical problem to be solved by the present invention is to develop a purification technology of repobufin base and cinobufin base in fresh toad venom based on the above-mentioned deficiencies. [0004] The technical scheme of the present invention is: the purification method is: after grinding fresh toad venom, add an organic solvent and stir to obtain a solution of toad venom, then place...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07J71/00
Inventor 王利忠
Owner 王利忠
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