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Biocollagen and its production process

A production process, collagen technology, applied in the preparation of animal glue or gelatin, etc., can solve the problems of insufficient compatibility with human body, poor biological activity of collagen, and destruction of biological activity of pigskin, etc., and achieve rapid and painless wound repair. Excellent effect on irritation, speed and ability to adhere to wound tissue

Inactive Publication Date: 2004-04-07
唐宝辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the existing production process is complicated, the production cycle is long, and the repeated acid-base soaking destroys the biological activity of pigskin and changes the properties of collagen in pigskin. Therefore, the biological activity of collagen produced by the above-mentioned process Poor, the compatibility with the human body does not meet the requirements, it is not easy to be absorbed by the human body, and it is easy to leave harmful substances, causing harm to the human body

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1) Choose healthy, painless, strong immunity, 1-month-old fragrant pigs, clean, slaughter, and skin them;

[0020] 2) Cook and remove the fat and meat layer in the skin through a skin slicer;

[0021] 3) Soak in edible chlorine water for 10 minutes;

[0022] 4) Soak in clean water for 15 minutes;

[0023] 5) Cook the pigskin with physiological saline at a temperature of 35°C and a pressure of 0.4MPa for 2 hours;

[0024] 6) Collecting and extracting the collagen, heating the collagen to 80°C within 1 minute, and maintaining it for 1 minute;

[0025] 7) Carry out microfiltration with a high-efficiency filter press;

[0026] 8) Pass through a grease separator to obtain fat-free pure glue;

[0027] 9) Use a high-pressure cold air blower to blow the glue solution, and the temperature of the cold air will gradually drop from minus 5°C to minus 30°C at a rate of one degree every 15 minutes, until the water content in the collagen is less than 10%.

[0028] 10) Sterility,...

Embodiment 2

[0033] 1) Choose healthy, painless, strong immunity, 3-month-old fragrant pigs, clean, slaughter, and skin them;

[0034] 2) Cook and remove the fat and meat layer in the skin through a skin slicer;

[0035] 3) Soak in edible chlorine water for 8 hours;

[0036] 4) Soak in clean water for 8 hours;

[0037] 5) Cook the pigskin with physiological saline at a temperature of 40°C and a pressure of 0.3 MPa for 3 hours;

[0038] 6) Collect and extract the collagen, and heat the collagen to 90°C within 1 minute and keep it for 1 minute;

[0039] 7) Carry out microfiltration with a high-efficiency filter press;

[0040] 8) Pass through a grease separator to obtain fat-free pure glue;

[0041] 9) Use a high-pressure cold air blower to blow the glue solution, and the temperature of the cold air will gradually drop from minus 5°C to minus 30°C at a rate of one degree every 25 minutes, until the water content in the collagen is less than 10%.

[0042] 10) Sterility, no bacterial endo...

Embodiment 3

[0045] 1) Choose healthy, painless, strong immunity, 1-month-old fragrant pigs, clean, slaughter, and skin them;

[0046] 2) Cook and remove the fat and meat layer in the skin through a skin slicer;

[0047] 3) Soak in edible chlorine water for 5 hours;

[0048] 4) Soak in clean water for 5 hours;

[0049] 5) Cook the pigskin with physiological saline, the cooking temperature is 40°C, the pressure is 0.2MPa, and the cooking time is 4 hours;

[0050] 6) Collecting and extracting the collagen, heating the collagen to 100°C within 0.5 minutes, and maintaining it for 2 minutes;

[0051] 7) Carry out microfiltration with a high-efficiency filter press;

[0052] 8) Pass through a grease separator to obtain fat-free pure glue;

[0053] 9) Use a high-pressure cold air blower to blow the glue solution, and the temperature of the cold air will gradually drop from minus 6°C to minus 40°C at a rate of one degree every 30 minutes, so that the moisture content in the collagen is less th...

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Abstract

The biocollagen with bioactivity is extracted form animal skin. The production process includes; selecting skin of health fragrant hog in 3 month age, eliminating hair and fat; sterlilzing, water washing, steaming in physiological saline at 30-40 deg.c temperature and 0.2-0.4 MPa pressure for 2-4 hr, extracting and degrading collagen at high temperature, filtering to purify, separating to eliminate fat and grease, freeze drying to dewater, and forming. The biocollagen has excellent bioactivity, good biocompatibility to human body, fast hemostasis function, no allergy, no stimulation, no toxic side effect, no rejection, easy absorption in human body and fast wound repairing function.

Description

(1) Technical field: [0001] The invention relates to gelatin extracted from animal skin, also known as protein collagen, in particular to biologically active biological collagen, and a production process for the above-mentioned collagen. (two) background technology: [0002] The protein collagen extracted from animal skin is called gelatin for short. It can be extracted from animal bone and skin. In fact, it is the first-class bone glue and skin glue with light color, high transparency and high purity. Existing gelatin all adopts common pigskin as raw material, and the application number as the inventor's application is 981046223, and the name is called "the technique of producing medicinal gelatin with broken leather" and the application number is 03117311.x, and the name is "biological absorption Hemostatic cotton and its production process" invention patent. Because ordinary pigskin is thick and hard, it must be soaked in alkaline solution such as lime water to make it f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09H3/00
Inventor 唐宝辉
Owner 唐宝辉
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