P-ethyl phenol aminophenol anal injection for children and its prepn

Abstract

The present invention is p-acetaminophenol anal injection as antipyretic analgesic for children and its preparation process. P-acetaminophenol anal injection consists of p-acetaminophenol as main material, supplementary material including propylene glycol, polyglycol-400, sodium bisulfite, Nipagin M and complexone III, and water. The medicine is injected into rectum directly and this can avoid pain and direct influence on liver, resulting in lowered toxicity and raised safety.

Description

technical field

[0001] The invention relates to an anal injection liquid of acetaminophen, an antipyretic and analgesic drug for fever, pain and other diseases in children, and a preparation method thereof. Background technique

[0002] Acetaminophen is a peripheral analgesic with an antipyretic effect similar to that of aspirin, and is generally effective for mild to moderate pain. At present, most of the dosage forms of acetaminophen are injections and oral preparations. These two dosage forms are not suitable for the treatment of children, because children are young and afraid of injections, and injections are inconvenient to use, and it is difficult to cooperate with oral administration. Forced gavage is often used, which often makes the medicine easy to pour into the trachea or vomit after taking it. , it is difficult to achieve the effective dose of medication. And when adopting the above method for administration, the medicine all will pass through the liver, and th...