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P-ethyl phenol aminophenol anal injection for children and its prepn

An acetaminophen and liquid injection technology, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of difficult to achieve effective dose of medicines, inconvenient use of injections, and easy infusion of medicines into the trachea. , to achieve the effect of reducing toxicity, good effect and avoiding pain

Inactive Publication Date: 2004-06-23
湖南康尔佳药业管理集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These two dosage forms are not suitable for the treatment of children, because children are young and afraid of injections, and injections are inconvenient to use, and it is difficult to cooperate with oral administration. Forced gavage is often used, which often makes the medicine easy to pour into the trachea or vomit after taking it. , it is difficult to achieve the effective dose of the drug
And when the above methods are used for administration, the drugs must pass through the liver, and the toxicity is relatively high.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] (1) Take 20kg of paracetamol, put it into a batching tank, add 70kg of purified water at 75°C, and stir for 15 minutes to dissolve;

[0012] (2) Get propylene glycol 70kg, Polyethylene Glycol-400 50kg drops into batching tank, stir 20 minutes;

[0013] (3) Take 0.2kg of sodium bisulfite, 0.09kg of methylparaben, and 0.06kg of disodium ethylenediaminetetraacetate and put them into the batching tank, stir for 3 hours, and pack it into a 2ml bottle containing 200mg of acetaminophen Anal injection.

[0014] This product is colorless or light yellow liquid. PH value is 4.5~6.5

Embodiment 2

[0016] (1) Take 25kg of paracetamol, put it into the batching tank, add 60kg of purified water at 70-80°C, and stir for 15 minutes to dissolve;

[0017] (2) Get propylene glycol 65kg, Polyethylene Glycol-400 45kg, drop into batching tank, stir 20 minutes;

[0018] (3) Take 0.2kg of sodium bisulfite, 0.09kg of paraben, and 0.06kg of disodium ethylenediaminetetraacetate, put them into the batching tank, stir for 3 hours, and send them to determine the content and PH value after passing the test, and fill them into each 2ml anal injection solution.

[0019] Valid for 2 years

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PUM

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Abstract

The present invention is p-acetaminophenol anal injection as antipyretic analgesic for children and its preparation process. P-acetaminophenol anal injection consists of p-acetaminophenol as main material, supplementary material including propylene glycol, polyglycol-400, sodium bisulfite, Nipagin M and complexone III, and water. The medicine is injected into rectum directly and this can avoid pain and direct influence on liver, resulting in lowered toxicity and raised safety.

Description

technical field [0001] The invention relates to an anal injection liquid of acetaminophen, an antipyretic and analgesic drug for fever, pain and other diseases in children, and a preparation method thereof. Background technique [0002] Acetaminophen is a peripheral analgesic with an antipyretic effect similar to that of aspirin, and is generally effective for mild to moderate pain. At present, most of the dosage forms of acetaminophen are injections and oral preparations. These two dosage forms are not suitable for the treatment of children, because children are young and afraid of injections, and injections are inconvenient to use, and it is difficult to cooperate with oral administration. Forced gavage is often used, which often makes the medicine easy to pour into the trachea or vomit after taking it. , it is difficult to achieve the effective dose of medication. And when adopting the above method for administration, the medicine all will pass through the liver, and th...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/165A61P29/00
Inventor 肖才松
Owner 湖南康尔佳药业管理集团有限公司
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