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Chinese traditional medicine preparation Qishenmai for treating coronary heart disease and angina pectoris and its preparing process

A technology of coronary heart disease angina pectoris and traditional Chinese medicine preparations, applied in the field of traditional Chinese medicine preparations, can solve the problems of affecting the therapeutic effect and application range of drugs, slow drug absorption, inconvenient use, etc., and achieve the effect of fast drug effect, good curative effect, and fast absorption

Inactive Publication Date: 2004-11-10
吉林迈迪星药物科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, coronary heart disease and angina pectoris have become a common disease in the field of medical internal medicine, which is extremely harmful, but so far there is no safe and effective traditional Chinese medicine preparation for injection; Oral decoction is used, and there is no traditional Chinese medicine injection form. For oral dosage forms, the drug smell is more, not only the body absorbs the drug slowly, but also inconvenient to use, which directly affects the therapeutic effect and application range of this type of drug.
[0003] Panax notoginseng, American ginseng and Ophiopogon japonicus are widely used as medicines for treating cardiovascular and other diseases, but there is no effective clinical treatment of coronary heart disease angina pectoris by combining three Chinese medicines of notoginseng, American ginseng and Ophiopogon japonicus in a certain proportion. preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] a. Preparation of extracts of American ginseng, Ophiopogon japonicus and Panax notoginseng

[0050](1) Take 0.75kg of American ginseng, 10kg of Ophiopogon japonicus, and 0.5kg of Panax notoginseng, and pulverize them into coarse powder, respectively, add 20 times of water, heat and boil three times.

[0051] (2) respectively collecting and merging the water extracts obtained from American ginseng, Ophiopogon japonicus and Panax notoginseng, respectively, and concentrating to 50°C with a relative density of 1.20;

[0052] (3) respectively the concentrated solution of American ginseng, Ophiopogon japonicus and Panax notoginseng respectively, add ethanol to alcohol concentration respectively and reach 85%, place respectively 24 hours, filter, filtrate reclaims ethanol, to no alcohol smell, dilution, filters;

[0053] (4) The filtrates of American ginseng, Ophiopogon japonicus and Panax notoginseng were respectively adsorbed through a macroporous adsorption resin column (D2...

Embodiment 2

[0058] a. Preparation of total extracts of American ginseng, Ophiopogon japonicus and Panax notoginseng

[0059] (1) Take 0.75kg of American ginseng, 10kg of Ophiopogon japonicus, and 0.5kg of Panax notoginseng, combine, mix and pulverize to coarse powder, add 20 times of water, heat and boil three times for 1 hour each time.

[0060] (2) collecting and merging the obtained aqueous extracts, concentrating to 80°C and having a relative density of 0.9;

[0061] (3) add ethanol to the concentrated solution until the alcohol concentration reaches 50%, place it for 24 hours, filter, and recycle ethanol from the filtrate until there is no alcohol smell, dilute, and filter to obtain a filtrate;

[0062] (4) The filtrate was adsorbed through a macroporous adsorption resin column (D21 type), and the resin column was eluted with 20% ethanol. After the eluent was colorless, the eluent was discarded and eluted with 50% concentration ethanol. Resin column, collect eluent;

[0063] (5) 50...

Embodiment 3

[0067] a. Preparation of total extracts of American ginseng stems and leaves, Ophiopogon japonicus and Panax notoginseng leaves

[0068] (1) Take 0.75 kg of American ginseng leaves, 10 kg of Ophiopogon japonicus, and 0.5 kg of Panax notoginseng leaves, combine, mix and pulverize into coarse powder, add 20 times of water, heat and boil three times for 1 hour each time.

[0069] (2) collecting and merging the obtained aqueous extracts, and concentrating to 60°C with a relative density of 1.10;

[0070] (3) add ethanol to the concentrated solution to an alcohol concentration of 70%, place it for 24 hours, filter, recycle ethanol from the filtrate, to have no alcohol smell, dilute, filter to obtain a filtrate;

[0071] (4) The filtrate was adsorbed through a macroporous adsorption resin column (type D21), and the resin column was eluted with 10% ethanol. After the eluent was colorless, the eluent was discarded and eluted with 60% concentration ethanol. Resin column, collect eluen...

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Abstract

The invention relates to Qishenmai, a traditional Chinese preparation for treating coronary disease and angina pectoris and process for preparation, and provides a Qishenmai injection, wherein the preparation process includes, merging ophiopogon root, pseudo-ginseng, root of American ginseng or American ginseng leaves proportionally, or extracting by boiling with water respectively, removing impurities through ethanol deposition, refining with big hole resin columns, purging with ethanol again, collecting the eluent, filtering, thus preparing pharmacologically acceptable freeze dried, tablet, granule, drop pill, electuary, fluid preparation, powder injection, pill, capsule and suspending agent, or solid dosage forms such as spray and aerosol suitable for local administration.

Description

Technical field: [0001] The invention relates to a traditional Chinese medicine preparation of Qishenmai for treating coronary heart disease angina pectoris and a preparation method thereof, and provides a Qishenmai injection, which belongs to the technical field of traditional Chinese medicine preparations. Background technique: [0002] At present, coronary heart disease angina pectoris has become a common disease in the field of medical internal medicine, which is extremely harmful, but there is no safe and effective traditional Chinese medicine preparation for injection. Decoction is taken orally, and there is no traditional Chinese medicine injection formulation. For oral formulations, the smell of medicine is not only slow for the body to absorb the drug, but also inconvenient to use, which directly affects the therapeutic effect and scope of use of this type of drug. [0003] Panax notoginseng, American ginseng and Ophiopogon japonicus are widely used as medicines for...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61P9/10
Inventor 徐东铭徐暾海刘平
Owner 吉林迈迪星药物科技发展有限公司
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