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Blood circulation promoting and pain alleviating soft capsule and its preparation

A soft capsule preparation and soft capsule technology, which is applied in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problems of high natural copper, copper and arsenic content, inaccurate dosage of powder ingredients, and difficulty in passing hygienic indicators and other issues, to achieve the effect of easy quality control, treatment of bruises, and high technological content

Inactive Publication Date: 2004-11-10
南京生物工程与医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been included in the ministerial standard [WS3-091(Z-81)-95(Z)]. The dosage of the powder is not accurate, and it is inconvenient to take. There are many problems in the hard capsule, such as taking a large amount, and each time needs 0 4-6 capsules. The borneol in the prescription is very irritating to the stomach, and it is difficult to pass the hygienic index. The content of copper and arsenic in natural copper is high, and long-term use has toxic side effects on the human body.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0121] prescription:

[0122] Angelica 400g, Panax notoginseng 80g, frankincense (made) 80g, borneol 20g, wood beetle 200g, natural copper (calcined) 120g.

[0123] Extract the volatile oil from Angelica sinensis, decoct the decoction after extracting the volatile oil, concentrate under reduced pressure to a relative density of 1.00-1.50, the best density is 1.20 (50°C), and set aside;

[0124] The natural copper is decocted first, the dregs are decocted with the wood beetle and natural copper twice, each time for 1 hour, the decoctions are combined, filtered, concentrated under reduced pressure to a relative density of 1.20 (50°C), and set aside;

[0125] The above concentrates were combined, added with ethanol for alcohol precipitation, the ethanol concentration was 80%, the supernatant was taken, the ethanol was recovered and concentrated under reduced pressure to a clear paste with a relative density of 1.18 (50°C), dried, pulverized, passed through a 100-mesh sieve, and s...

Embodiment 2

[0129] prescription:

[0130] Angelica 400g, Panax notoginseng 80g, frankincense (made) 80g, borneol 20g, wood beetle 200g, natural copper (calcined) 120g.

[0131] Extract the volatile oil from Angelica sinensis and collect it for later use;

[0132] Decoct the natural copper first, decoct the dregs, ground beetle, and natural copper twice, each time for 1 hour, combine the decoction, filter, concentrate under reduced pressure to a relative density of 1.20 (50°C), dry, crush, and sieve through a 100-mesh sieve ,spare;

[0133] Radix Notoginseng and frankincense were extracted twice with 75% ethanol, the extract was recovered, the ethanol was recovered, concentrated under reduced pressure to a clear paste with a relative density of 1.18 (50°C), dried, pulverized, sieved through a 100-mesh sieve, and set aside;

[0134] Crush borneol, pass through a 100-mesh sieve, and set aside;

[0135] Take each fine powder obtained above, mix evenly, add volatile oil to obtain the active...

Embodiment 3

[0137] prescription:

[0138] Angelica 400g, Panax notoginseng 80g, frankincense (made) 80g, borneol 20g, wood beetle 200g, natural copper (calcined) 120g.

[0139] Extract the volatile oil from Angelica sinensis and collect it for later use;

[0140] Decoct the natural copper first, decoct the medicinal dregs and natural copper twice, 1 hour each time, combine the decoction, filter, concentrate under reduced pressure to a relative density of 1.20 (50°C), dry, pulverize, pass through a 100-mesh sieve, and set aside ;

[0141] Radix Notoginseng and frankincense are extracted twice with 50% ethanol, the extract is recovered, the ethanol is recovered, concentrated under reduced pressure to a clear paste with a relative density of 1.18 (50°C), dried, pulverized, sieved through a 100-mesh sieve, and set aside;

[0142] Crush borneol, pass through a 100-mesh sieve, and set aside;

[0143] Add 8 times the amount of water to the ground beetle, decoct for 0.5 hours, and after the temp...

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PUM

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Abstract

The invention relates to a soft capsule preparation for promoting blood circulation and relieving pain, its preparation method and forming process, wherein the preparation mainly comprises Chinese angelica root, native copper, notoginseng, frank incense and borneol. The invention discloses three processes for preparation which mainly comprises directly disintegrating part of the medicinal material, extracting different active ingredient, charging right amount of rationalized findings, grinding, stirring continuously, obtaining stock liquor, making soft capsule peel with gelatin, pressing the stock liquor and soft capsule peel into soft capsule.

Description

Technical field: [0001] The invention relates to a soft capsule preparation for promoting blood circulation and relieving pain and a preparation method thereof, in particular to a traditional Chinese medicine for promoting blood circulation and relieving pain made from angelica, notoginseng, frankincense, borneol, wood beetle, and natural copper, and belongs to the field of pharmaceutical preparations . Background technique: [0002] The Huoxue Zhitong Soft Capsule of the present invention, its prescription originated from Huoxue Zhitong Powder in "Qian Jin Fang" by Sun Simiao, a famous doctor in Tang Dynasty, which is now recorded in "Pharmacopia of the People's Republic of China" (2000 edition). Huoxue Zhitong Soft Capsules is a soft capsule preparation that has been improved on this basis. [0003] The traditional Chinese medicine for promoting blood circulation and relieving pain made of angelica, notoginseng, frankincense, borneol, wood beetle, and natural copper has r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K35/64A61P25/00
Inventor 储益平王殿广时贞平朱春霞
Owner 南京生物工程与医药科技发展有限公司
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