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Anticancer nanometer targeted administered prescription

A kind of anticancer drug and nanotechnology, which is applied in the direction of anticancer drugs, drug combinations, and non-active ingredients of polymer compounds, etc., can solve the problems of inconvenient application of magnetic targeting, complicated production process, and inability to accurately locate, etc., and achieve convenient large-scale Industrialized production, simple production process, and the effect of improving drug efficacy and specific conductivity

Inactive Publication Date: 2004-11-17
江西医学院
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AI Technical Summary

Problems solved by technology

Many research reports focus on connecting monoclonal antibodies or making magnetic targeting drug delivery systems. The use of monoclonal antibodies to "guidance" has high production costs and complicated production processes. The application of magnetic targeting is inconvenient and cannot be accurately positioned.

Method used

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Examples

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Embodiment Construction

[0006] The invention links folic acid with bovine serum albumin as a material for preparing nanospheres, and then encapsulates anticancer drugs (doxorubicin, etc.) to make nanospheres. Its specific preparation process method is as follows: first folic acid (or 5MeH 4 Folic acid) was dissolved in dimethyl sulfoxide, and incubated with 2-10 times 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide at 23°C for 30min to activate folic acid, then added BSA and incubated at 23°C 4h, add ethanolamine, and finally use Sephadex G-25 column to separate to obtain folic acid-BSA, then use folic acid-BSA as material to prepare drug-loaded nanospheres, and use HPLC method to determine the content of doxorubicin in nanospheres.

[0007] HPLC content determination method

[0008] After dissolving the nanospheres, extract doxorubicin with methanol, and measure according to the following method: HPLC chromatographic conditions, YMC-C18H37 chromatographic column (300mm×5mm), mobile phase is methanol...

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Abstract

The invention discloses an anti-cancer targeting nano medicine administration preparation, wherein folic acid is connected with cow blood albumen to form the material for preparing nano balls, then the anti-cancer drugs are encapsulated. By using nano balls as the carrying agent, good constancy has been realized. íí

Description

technical field [0001] The invention relates to an anticancer drug targeted nano drug delivery preparation. Background technique [0002] Malignant tumors are common and frequently-occurring diseases that seriously threaten human life and health. In recent years, according to statistics, there are about 4.5 million patients who die of cancer every year in the world, while about 1 million people die of cancer in my country. All countries in the world are paying attention to the research on the prevention and treatment of cancer. Most of the chemotherapeutic drugs currently used clinically use the principle of rapid proliferation of cancer cells to inhibit or kill cancer cells, but normal tissues such as bone marrow cells also have the ability to proliferate rapidly, so the toxic and side effects of most chemotherapeutic drugs also increase with the increase. Therefore, people are looking for "guide" of anticancer drugs to improve the targeting of dru...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/42A61P35/00
Inventor 朱亮李少华
Owner 江西医学院
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