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Time release calcium sulfate matrix for bone augmentation

A calcium sulfate, matrix technology, used in bone implants, aluminum/calcium/magnesium active ingredients, compression mold cups, etc., can solve the problem of exceeding the speed of new bone formation in patients

Inactive Publication Date: 2004-11-24
奥斯欧根有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a result, the focus and difficulty faced by physicians such as orthopedic surgeons or maxillofacial surgeons is that calcium sulfate materials bioabsorb or dissolve at the surgical or implant site so quickly that they outpace the patient's rate of new bone formation

Method used

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  • Time release calcium sulfate matrix for bone augmentation
  • Time release calcium sulfate matrix for bone augmentation
  • Time release calcium sulfate matrix for bone augmentation

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Embodiment Construction

[0018] In one aspect, the present invention provides an implant composition having a controlled rate of resorption comprising a calcium sulfate compound, polymer-containing particles, and a curing agent for incorporating the calcium sulfate compound and the polymer-containing The particles of the substance solidify into a multiphase solid composition. Upon solidification, the calcium sulphate compound forms a matrix (M) in which the polymer-containing particles (P) are located. figure 1 Shown is a cross-sectional view of the heterogeneous solid implant composition before resorption occurs.

[0019] In another aspect, the present invention includes methods of using implant materials to prepare implant compositions of the present invention for bone augmentation and bone defect repair. The method comprises the steps of: (a) mixing calcium sulfate compound and polymer-containing particles with a curing agent into a mixture, (b) filling said mixture into an implant site, and (c) c...

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Abstract

An implant composition having controlled resorption rate in vivo for stimulating bone growth, a method of making the implant composition, and a kit of implant materials are disclosed. The implant composition includes a calcium sulfate compound, polymer containing particles, and a setting agent for setting the calcium sulfate compound and the polymer containing particles into a heterogeneous solid composition. Upon setting, the calcium sulfate compound forms a matrix and the polymer containing particles settled within the matrix. The resorption rate of the implant composition in vivo can be controlled of between eight and twenty-four weeks, which substantially matches the rate of bone growth. The implant composition of the present invention can be used for the repair, augmentation, and other treatment of bone.

Description

technical field [0001] The present invention relates to an implant composition for stimulating bone growth and having a controlled absorption rate in the body, and relates to a preparation method of the implant composition and an implant material kit. Background technique [0002] Repair of bone defects and augmentation of existing bone often require the use of permanent bioabsorbable materials. These materials may include autograft bone, allograft bone, or allogeneic plastic materials including various calcium phosphate porcelain materials, calcium phosphate bone materials, and composites or other combinations thereof. Cement, calcium sulfate materials and bioglass materials. Calcium sulfate, a calcined plaster, is a fully bioabsorbable material, and calcium sulfate in the form of bone cement and pellets is often used to repair bone defects. [0003] When calcium sulfate is used as bone cement to fill bone spaces, fractures or other defects, this material dissolves at a r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/00A61F2/00A61F2/02A61F2/28A61F2/30A61K6/884A61K6/891A61L27/02A61L27/44
CPCA61F2250/003A61F2002/3085A61F2002/30838A61L27/446A61L2430/02A61F2002/30062A61F2210/0004A61F2/28A61F2002/2835A61F2002/30032A61F2/30767A61L27/025A61F2002/30064C08L67/04A61K33/06
Inventor 约翰·L·雷西哈罗德·亚历山大布鲁斯·L·霍兰德
Owner 奥斯欧根有限公司
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