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High nurity beta-elemene medicine and its preparing method

A high-purity technology for elemene, which is applied in the field of high-purity β-elemene medicine and its preparation, can solve the problems of low probability of occurrence and low average content, so as to increase the content of active ingredients, reduce toxic and side effects, The effect of improving the curative effect

Inactive Publication Date: 2004-12-15
YUANDA INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the content of β-elemene in the prepared medicine can reach 99.9%, the probability of occurrence is small, and its average content is still low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] a. Use citronella grass as the starting material, extract citronella oil from citronella grass, and extract the leftovers after extracting the essence from the oil, and then continue to process it into the raw material for extracting β-elemene from the fragrance chemical factory, that is, the content of β-elemene Be the raw material of 80~92% (percentage by weight);

[0022] b. Place the raw materials in the precision fractionation tower heating kettle for precision fractionation. The volume of the heating shaft can be 3000ml. The height of the fractionation column is 140cm, the diameter is 3.5cm, and the cylinder of 3mm×3mm stainless steel mesh is used as the filler, and the vacuum degree is 500Pa. , control the flow rate ratio 5: 1, collect the cut when temperature is 82~83 ℃, detect with gas chromatograph, the collected cut contains β-elemene 92~96%;

[0023] c. Carry out secondary fractionation with the cut obtained in step b as raw material in the precision fractio...

Embodiment 2

[0026] a. Taking elemene as the raw material, place the raw material in a heating kettle of a precision fractionation tower for precision fractionation. The volume of the heating ax is 2500ml, the height of the fractionation column is 140cm, and the diameter is 3.5cm. The body is a filler, the vacuum is 200Pa, the control flow rate ratio is 5: 1, and the fraction collected at a temperature of 82 to 83° C. is a raw material with a content of β-elemene of 80 to 92% (percentage by weight);

[0027] B. place the fraction obtained in a step as a raw material in a heating tank of a precision fractionation tower for secondary fractionation, the fractionation conditions are the same as in step a, and its fraction contains 92% to 96% of beta-elemene;

[0028] c. using the fraction obtained in the b step as a raw material and placing it in a precision fractionation tower heating kettle for secondary fractionation, the fractionation conditions are the same as in the b step, and the fracti...

Embodiment 3

[0031] A. get the raw material that contains 80~92% (percentage by weight) β-elemene, can be as embodiment 1 or embodiment 2;

[0032] b. Place the raw material obtained in step a into a precision fractionation tower heating kettle for precision fractionation. The volume of the heating ax is 2500-3500ml, with a 3mm×3mm stainless steel mesh cylinder as the filler, the vacuum degree is 200-500Pa, and the flow rate ratio is controlled at 5 : 1, the cut when collecting temperature is 82~83 ℃, its cut contains β-elemene 92~96%;

[0033] c. using the fraction obtained in the b step as a raw material and placing it in a precision fractionation tower heating kettle for secondary fractionation, the fractionation conditions are the same as in the b step, and the fraction contains 96% to 98% of beta-elemene;

[0034] d. Carry out high-pressure column chromatography using the fraction obtained in step c as a raw material. Take a stainless steel column with a length of 100 cm and a diamet...

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Abstract

The present invention discloses a kind of high-purity elemene medicine, which features the beta-elemene content as high as 98-99.9 wt%. One of its preparation process includes twice precise fractionation of elemene material containing beta-elemene of 80-92 wt% inside one heating reactor in precise fractionating tower with stainless steel cylinders as stuffing at vacuum degree of 200-500 Pa, flow rate ratio of 5 to 1 to collect the fraction at temperature of 82-83 deg.c. One other preparation process includes twice precise fractionation, and column chromatographic separation to eliminate impurity with the chromatographic column stuffed with silica gel after activation at 115-125 deg.c for 1.5 hr, and has even high beta-elemene content.

Description

Technical field: [0001] The invention relates to a beta-elemene medicine and a preparation method thereof, in particular to a high-purity beta-elemene medicine with a beta-elemene content of 98-99.9% and a preparation method thereof. Background technique: [0002] Elemene is an effective component of zedoary oil, and the previous extraction method made the content of the active component β-elemene low. The national second-class anti-cancer drug elemene has been widely recognized for its obvious anti-cancer effect and low toxic and side effects, but the content of β-elemene is only 55%. Although the content of β-elemene in the national first-class new drug β-elemene, which is an alternative product of elemene, has increased, its content is also relatively low, only 96.4%. It is recorded in the patent specification. Since the purity of chemical medicines is an important indicator of quality, curative effect and toxic side effects, people are seeking methods for preparing hig...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61P35/00C07C7/04C07C13/23
Inventor 陈玉仁吴秀英
Owner YUANDA INT
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