High nurity beta-elemene medicine and its preparing method

Abstract

The present invention discloses a kind of high-purity elemene medicine, which features the beta-elemene content as high as 98-99.9 wt%. One of its preparation process includes twice precise fractionation of elemene material containing beta-elemene of 80-92 wt% inside one heating reactor in precise fractionating tower with stainless steel cylinders as stuffing at vacuum degree of 200-500 Pa, flow rate ratio of 5 to 1 to collect the fraction at temperature of 82-83 deg.c. One other preparation process includes twice precise fractionation, and column chromatographic separation to eliminate impurity with the chromatographic column stuffed with silica gel after activation at 115-125 deg.c for 1.5 hr, and has even high beta-elemene content.

Description

Technical field:

[0001] The invention relates to a beta-elemene medicine and a preparation method thereof, in particular to a high-purity beta-elemene medicine with a beta-elemene content of 98-99.9% and a preparation method thereof. Background technique:

[0002] Elemene is an effective component of zedoary oil, and the previous extraction method made the content of the active component β-elemene low. The national second-class anti-cancer drug elemene has been widely recognized for its obvious anti-cancer effect and low toxic and side effects, but the content of β-elemene is only 55%. Although the content of β-elemene in the national first-class new drug β-elemene, which is an alternative product of elemene, has increased, its content is also relatively low, only 96.4%. It is recorded in the patent specification. Since the purity of chemical medicines is an important indicator of quality, curative effect and toxic side effects, people are seeking methods for preparing hig...